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Q0APT3

- FTHS_MARMM

UniProt

Q0APT3 - FTHS_MARMM

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Mmar10_1412
Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-1439-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Mmar10_1412
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000300529Add
BLAST

Proteomic databases

PRIDEiQ0APT3.

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_1412.

Structurei

3D structure databases

ProteinModelPortaliQ0APT3.
SMRiQ0APT3. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiACEEETE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0APT3-1 [UniParc]FASTAAdd to Basket

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MTSDIEIARA ATLKPMAAIA ARLGIPDEAI IPFGRSKAKL SGDFIATLKD    50
RPRGKLILVT AISPTPAGEG KTTTTVGLGD GLSRIGKKVA ICLREPSLGP 100
CFGMKGGAAG GGMAQVVPME DINLHFTGDF HAITSAHNLL AALIDNHVHW 150
GNEQQIDSRR IALRRVLDMN DRSLRNLVTG LGGPAHGTPR EGGFDITVAS 200
EVMAILCLAR DLADLEERLG DIVIAERADR SRVTARDIGA AGAMTVLLKD 250
AFQPNLVQTL EHTPTFIHGG PFANIAHGCN TLVATDTALR LADYVVTEAG 300
FGADLGAEKF FDIKCRKGGL EPSAAVLVAT IRALKMNGGV PKDQLGAENV 350
AAVEAGCANL GRHIENLAKF GVPVVVAINH FTADSEAEVA AVEAFCEARG 400
VKAVLATHWA EGGQGTQKLA EAVSELVEGG SSRFAPLYPD DMPLVDKIET 450
VAQSIYRAGS VVFERSARLQ LERWQEAGYG HLPVCMAKTQ YSFSADPALT 500
GAPEGHELPV REVRLSAGAG FVVAVCGAIM TMPGLPRKPA ALDIHLNAEG 550
EVEGLF 556
Length:556
Mass (Da):58,529
Last modified:October 17, 2006 - v1
Checksum:i605297BA8000F4C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65704.1.
RefSeqiWP_011643351.1. NC_008347.1.
YP_756642.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI65704; ABI65704; Mmar10_1412.
GeneIDi4286148.
KEGGimmr:Mmar10_1412.
PATRICi22450918. VBIMarMar77530_1449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65704.1 .
RefSeqi WP_011643351.1. NC_008347.1.
YP_756642.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0APT3.
SMRi Q0APT3. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_1412.

Proteomic databases

PRIDEi Q0APT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI65704 ; ABI65704 ; Mmar10_1412 .
GeneIDi 4286148.
KEGGi mmr:Mmar10_1412.
PATRICi 22450918. VBIMarMar77530_1449.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi ACEEETE.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MMAR394221:GHNB-1439-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiFTHS_MARMM
AccessioniPrimary (citable) accession number: Q0APT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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