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Q0APT3 (FTHS_MARMM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Mmar10_1412
OrganismMaricaulis maris (strain MCS10) [Complete proteome] [HAMAP]
Taxonomic identifier394221 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300529

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0APT3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 605297BA8000F4C7

FASTA55658,529
        10         20         30         40         50         60 
MTSDIEIARA ATLKPMAAIA ARLGIPDEAI IPFGRSKAKL SGDFIATLKD RPRGKLILVT 

        70         80         90        100        110        120 
AISPTPAGEG KTTTTVGLGD GLSRIGKKVA ICLREPSLGP CFGMKGGAAG GGMAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDF HAITSAHNLL AALIDNHVHW GNEQQIDSRR IALRRVLDMN DRSLRNLVTG 

       190        200        210        220        230        240 
LGGPAHGTPR EGGFDITVAS EVMAILCLAR DLADLEERLG DIVIAERADR SRVTARDIGA 

       250        260        270        280        290        300 
AGAMTVLLKD AFQPNLVQTL EHTPTFIHGG PFANIAHGCN TLVATDTALR LADYVVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRKGGL EPSAAVLVAT IRALKMNGGV PKDQLGAENV AAVEAGCANL 

       370        380        390        400        410        420 
GRHIENLAKF GVPVVVAINH FTADSEAEVA AVEAFCEARG VKAVLATHWA EGGQGTQKLA 

       430        440        450        460        470        480 
EAVSELVEGG SSRFAPLYPD DMPLVDKIET VAQSIYRAGS VVFERSARLQ LERWQEAGYG 

       490        500        510        520        530        540 
HLPVCMAKTQ YSFSADPALT GAPEGHELPV REVRLSAGAG FVVAVCGAIM TMPGLPRKPA 

       550 
ALDIHLNAEG EVEGLF 

« Hide

References

[1]"Complete sequence of Maricaulis maris MCS10."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCS10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000449 Genomic DNA. Translation: ABI65704.1.
RefSeqYP_756642.1. NC_008347.1.

3D structure databases

ProteinModelPortalQ0APT3.
SMRQ0APT3. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394221.Mmar10_1412.

Proteomic databases

PRIDEQ0APT3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI65704; ABI65704; Mmar10_1412.
GeneID4286148.
KEGGmmr:Mmar10_1412.
PATRIC22450918. VBIMarMar77530_1449.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycMMAR394221:GHNB-1439-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_MARMM
AccessionPrimary (citable) accession number: Q0APT3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways