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Q0APT3

- FTHS_MARMM

UniProt

Q0APT3 - FTHS_MARMM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR394221:GHNB-1439-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Mmar10_1412
    OrganismiMaricaulis maris (strain MCS10)
    Taxonomic identifieri394221 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
    ProteomesiUP000001964: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300529Add
    BLAST

    Proteomic databases

    PRIDEiQ0APT3.

    Interactioni

    Protein-protein interaction databases

    STRINGi394221.Mmar10_1412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0APT3.
    SMRiQ0APT3. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiACEEETE.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0APT3-1 [UniParc]FASTAAdd to Basket

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    MTSDIEIARA ATLKPMAAIA ARLGIPDEAI IPFGRSKAKL SGDFIATLKD    50
    RPRGKLILVT AISPTPAGEG KTTTTVGLGD GLSRIGKKVA ICLREPSLGP 100
    CFGMKGGAAG GGMAQVVPME DINLHFTGDF HAITSAHNLL AALIDNHVHW 150
    GNEQQIDSRR IALRRVLDMN DRSLRNLVTG LGGPAHGTPR EGGFDITVAS 200
    EVMAILCLAR DLADLEERLG DIVIAERADR SRVTARDIGA AGAMTVLLKD 250
    AFQPNLVQTL EHTPTFIHGG PFANIAHGCN TLVATDTALR LADYVVTEAG 300
    FGADLGAEKF FDIKCRKGGL EPSAAVLVAT IRALKMNGGV PKDQLGAENV 350
    AAVEAGCANL GRHIENLAKF GVPVVVAINH FTADSEAEVA AVEAFCEARG 400
    VKAVLATHWA EGGQGTQKLA EAVSELVEGG SSRFAPLYPD DMPLVDKIET 450
    VAQSIYRAGS VVFERSARLQ LERWQEAGYG HLPVCMAKTQ YSFSADPALT 500
    GAPEGHELPV REVRLSAGAG FVVAVCGAIM TMPGLPRKPA ALDIHLNAEG 550
    EVEGLF 556
    Length:556
    Mass (Da):58,529
    Last modified:October 17, 2006 - v1
    Checksum:i605297BA8000F4C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI65704.1.
    RefSeqiWP_011643351.1. NC_008347.1.
    YP_756642.1. NC_008347.1.

    Genome annotation databases

    EnsemblBacteriaiABI65704; ABI65704; Mmar10_1412.
    GeneIDi4286148.
    KEGGimmr:Mmar10_1412.
    PATRICi22450918. VBIMarMar77530_1449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000449 Genomic DNA. Translation: ABI65704.1 .
    RefSeqi WP_011643351.1. NC_008347.1.
    YP_756642.1. NC_008347.1.

    3D structure databases

    ProteinModelPortali Q0APT3.
    SMRi Q0APT3. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 394221.Mmar10_1412.

    Proteomic databases

    PRIDEi Q0APT3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI65704 ; ABI65704 ; Mmar10_1412 .
    GeneIDi 4286148.
    KEGGi mmr:Mmar10_1412.
    PATRICi 22450918. VBIMarMar77530_1449.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi ACEEETE.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci MMAR394221:GHNB-1439-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MCS10.

    Entry informationi

    Entry nameiFTHS_MARMM
    AccessioniPrimary (citable) accession number: Q0APT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3