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Q0APT3

- FTHS_MARMM

UniProt

Q0APT3 - FTHS_MARMM

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-1439-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Mmar10_1412
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300529Add
BLAST

Proteomic databases

PRIDEiQ0APT3.

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_1412.

Structurei

3D structure databases

ProteinModelPortaliQ0APT3.
SMRiQ0APT3. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiACEEETE.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0APT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSDIEIARA ATLKPMAAIA ARLGIPDEAI IPFGRSKAKL SGDFIATLKD
60 70 80 90 100
RPRGKLILVT AISPTPAGEG KTTTTVGLGD GLSRIGKKVA ICLREPSLGP
110 120 130 140 150
CFGMKGGAAG GGMAQVVPME DINLHFTGDF HAITSAHNLL AALIDNHVHW
160 170 180 190 200
GNEQQIDSRR IALRRVLDMN DRSLRNLVTG LGGPAHGTPR EGGFDITVAS
210 220 230 240 250
EVMAILCLAR DLADLEERLG DIVIAERADR SRVTARDIGA AGAMTVLLKD
260 270 280 290 300
AFQPNLVQTL EHTPTFIHGG PFANIAHGCN TLVATDTALR LADYVVTEAG
310 320 330 340 350
FGADLGAEKF FDIKCRKGGL EPSAAVLVAT IRALKMNGGV PKDQLGAENV
360 370 380 390 400
AAVEAGCANL GRHIENLAKF GVPVVVAINH FTADSEAEVA AVEAFCEARG
410 420 430 440 450
VKAVLATHWA EGGQGTQKLA EAVSELVEGG SSRFAPLYPD DMPLVDKIET
460 470 480 490 500
VAQSIYRAGS VVFERSARLQ LERWQEAGYG HLPVCMAKTQ YSFSADPALT
510 520 530 540 550
GAPEGHELPV REVRLSAGAG FVVAVCGAIM TMPGLPRKPA ALDIHLNAEG

EVEGLF
Length:556
Mass (Da):58,529
Last modified:October 17, 2006 - v1
Checksum:i605297BA8000F4C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65704.1.
RefSeqiYP_756642.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI65704; ABI65704; Mmar10_1412.
GeneIDi4286148.
KEGGimmr:Mmar10_1412.
PATRICi22450918. VBIMarMar77530_1449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI65704.1 .
RefSeqi YP_756642.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0APT3.
SMRi Q0APT3. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_1412.

Proteomic databases

PRIDEi Q0APT3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI65704 ; ABI65704 ; Mmar10_1412 .
GeneIDi 4286148.
KEGGi mmr:Mmar10_1412.
PATRICi 22450918. VBIMarMar77530_1449.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi ACEEETE.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MMAR394221:GHNB-1439-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiFTHS_MARMM
AccessioniPrimary (citable) accession number: Q0APT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3