Reviewed, UniProtKB/Swiss-Prot Q0AP92 (HUTH_MARMM)

Names and origin

Protein names

Recommended name:
    Histidine ammonia-lyase
      Short name=Histidase
    EC=4.3.1.3

Gene names

Name:	hutH
Ordered Locus Names:	Mmar10_1603

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidine = urocanate + NH3. HAMAP MF_00229
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. HAMAP MF_00229
Subcellular location	Cytoplasm Potential.
Post-translational modification	Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly By similarity.
Sequence similarities	Belongs to the PAL/histidase family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro histidine catabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ammonia ligase activity Inferred from electronic annotation. Source: InterPro histidine ammonia-lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Histidine ammonia-lyase HAMAP MF_00229		PRO_0000336585
Amino acid modifications
	Modified residue	143	1	2,3-didehydroalanine (Ser) By similarity
	Cross-link	142 ↔ 144		5-imidazolinone (Ala-Gly) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0AP92-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: BB3F77F890CA662E	FASTA	507	52,202
	10 20 30 40 50 60 MTTVTIKPGA MVLADWADIW RGATIRIDPE AKAGVDAAAA TVDRLIASGE AVYGLNTGFG 70 80 90 100 110 120 KLAQTRIADD ELATLQERLV LSHAAGIGEA LDSRIVRLVM ALKLASLGRG ASGVRWTTIA 130 140 150 160 170 180 AMQALLDADV LPVIPSQGSV GASGDLAPLA HMSAALIGAG EATWQGQRMP ASDALAKAGL 190 200 210 220 230 240 KPVQLGPKEG LALLNGTQTS TALALAGLFE VEAGFQAALV SGALSVDAAK GSVAPFDPRI 250 260 270 280 290 300 HSLRGHPGQI DVAAALRGLL DGSGILSSHE GCEKIQDPYC LRCQPQVMGA VLDLLRQAGA 310 320 330 340 350 360 VLEREANAVT DNPLIFTDTD EAISGGNFHA EPVAFAADQI AMAACEIGSI CERRIALLTD 370 380 390 400 410 420 PAVSGLPAFL TPNPGINSGF MIAHVTAAAL VSENKQKAYP ASVDSIPTSA NQEDHVSMAT 430 440 450 460 470 480 HGAFRLLKMA ENLHVVVGIE LLCGAQGTDF HAGLTSSPTL ETAKATLRKQ VPAYGDDRYF 490 500 ATDIANARDL VTGRGLVADA GTLPGIA

References

[1]

"Complete sequence of Maricaulis maris MCS10." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000449 Genomic DNA. Translation: ABI65895.1.
RefSeq	YP_756833.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4283925.
GenomeReviews	Gene locus Mmar10_1603 in contig CP000449_GR.
KEGG	mmr:Mmar10_1603.
NMPDR	fig|394221.5.peg.1566.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0AP92.
OMA	Q0AP92. FAPDIEA.
Family and domain databases
HAMAP	MF_00229. [Tree]
InterPro	IPR005921. HutH. IPR001106. Phe/His_NH3-lyase. [Graphical view]
Pfam	PF00221. PAL. 1 hit. [Graphical view]
TIGRFAMs	TIGR01225. hutH. 1 hit.
PROSITE	PS00488. PAL_HISTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HUTH_MARMM

Accession

Primary (citable) accession number: Q0AP92

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)