Reviewed, UniProtKB/Swiss-Prot Q0AP91 (HUTI_MARMM)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Mmar10_1604

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Imidazolonepropionase HAMAP MF_00372		PRO_0000306472
Sites
	Metal binding	69	1	Zinc or iron By similarity
	Metal binding	71	1	Zinc or iron By similarity
	Metal binding	239	1	Zinc or iron By similarity
	Metal binding	314	1	Zinc or iron By similarity
	Binding site	78	1	Substrate By similarity
	Binding site	91	1	Substrate By similarity
	Binding site	141	1	Substrate By similarity
	Binding site	174	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0AP91-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 7EFC49E6950AA33D	FASTA	402	42,417
	10 20 30 40 50 60 MQFDRLLTEA RLATMVAGDD GYGVIEKAAL GIKDGRIAWI GPMSEIPGEA RETERLASRW 70 80 90 100 110 120 VTPALIDCHT HLVFAGDRSD EFERRLGGES YESISRSGGG IARSVEATRA AGAAELAAGA 130 140 150 160 170 180 LTRIDALAQE GVGTVEIKSG YGLTRESERT MLRAARGVER ASGMRVSATL LAAHAVPPEY 190 200 210 220 230 240 KGESGRYIDE ICIPLIREAA REGLADAVDA YCEGIGFSPE ETRRLFIAAK AAGLPVKLHA 250 260 270 280 290 300 DQLSDTGGAR LVAEFGGLSA DHIEYTNAEG IAAMAKAGTV GVLLPGAFYA LNETKKPPVE 310 320 330 340 350 360 AMRAAGVDMA VATDANPGTS PLVSLLTAAN MACILFGLTL PEAFAGMTRN AARALGLHGE 370 380 390 400 IGTLEVGKAA DLAIWDVERP AEIIQWIGRR PLHGRILAGE WQ

References

[1]

"Complete sequence of Maricaulis maris MCS10." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000449 Genomic DNA. Translation: ABI65896.1.
RefSeq	YP_756834.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4283926.
GenomeReviews	Gene locus Mmar10_1604 in contig CP000449_GR.
KEGG	mmr:Mmar10_1604.
NMPDR	fig|394221.5.peg.1567.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0AP91.
OMA	Q0AP91. MNMACTL.
Family and domain databases
HAMAP	MF_00372. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR005920. HutI. [Graphical view]
Pfam	PF01979. Amidohydro_1. 2 hits. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_MARMM

Accession

Primary (citable) accession number: Q0AP91

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)