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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Mmar10_2081
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
Proteomesi
  • UP000001964 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei175 – 195HelicalUniRule annotationAdd BLAST21
Transmembranei206 – 226HelicalUniRule annotationAdd BLAST21
Transmembranei243 – 263HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei295 – 315HelicalUniRule annotationAdd BLAST21
Transmembranei344 – 364HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000710491 – 367Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST367

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_2081.

Structurei

3D structure databases

SMRiQ0AMW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0AMW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLLFAPLA DDFQLANLFR YITFRTGGAL MTAMLIAFVF GKPMIGWLRR
60 70 80 90 100
KQGKGQPIRA EGIERHVVEK AGTPTMGGFL ILLGVMVGTL LWADLTNAYV
110 120 130 140 150
WIVIFVTAGF GVIGFIDDYL KVTKQTTAGF GGRFKLVGEF AIALIAVVWA
160 170 180 190 200
THTARSLGVE PGIETSIAVP FFKDLMINIG PLFFVFGCVV IVGSGNAVNM
210 220 230 240 250
TDGLDGLAIV PVMIAAATFG VIAYVVGRVD FAEYLQVHYT AGAGEILIFC
260 270 280 290 300
GALIGAGIGF LWWNAPPAMV FMGDTGSLSL GGALGTIAVA IKHELVLAIV
310 320 330 340 350
GGLFVLELVS VMVQVASFKL FGKRVFRMAP IHHHFEKKGW AEPTIVIRFW
360
IIAVILALIG LATLKLR
Length:367
Mass (Da):39,501
Last modified:October 17, 2006 - v1
Checksum:iD5CC3BD8C7B4DAE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000449 Genomic DNA. Translation: ABI66373.1.
RefSeqiWP_011644018.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI66373; ABI66373; Mmar10_2081.
KEGGimmr:Mmar10_2081.

Similar proteinsi

Entry informationi

Entry nameiMRAY_MARMM
AccessioniPrimary (citable) accession number: Q0AMW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families