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Q0AMJ2 (GCSPA_MARMM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Mmar10_2209
OrganismMaricaulis maris (strain MCS10) [Complete proteome] [HAMAP]
Taxonomic identifier394221 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045667

Sequences

Sequence LengthMass (Da)Tools
Q0AMJ2 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 6C3833CB7510CA34

FASTA44748,030
        10         20         30         40         50         60 
MRYLPHTDTD RKAMLDAIGV ASIDDLFTDV PEAARLDGLI DLPTKQTELQ VERALAAMSS 

        70         80         90        100        110        120 
RNVAASHAPF FVGAGAYKHH VPATVDHLIQ RSEFLTAYTP YQPEISQGTL QTLFEFQTQV 

       130        140        150        160        170        180 
ALLTGMDVAN ASMYDGSTAC AEAVMMAARV TRRTKAVMAG SVHPHYVEAS QTLAKYSDVS 

       190        200        210        220        230        240 
ISVTDAAPAD LDAVIAEIDD TTACVVIQTP DIFGRLHDLR EVSRIAHEKG ALVIAVFTEA 

       250        260        270        280        290        300 
VSLGLVEAPG HMGADIAVGE GQSIGVGLNF GGPYVGLFAC KDDRRFIRQM PGRLAGETID 

       310        320        330        340        350        360 
ADGRRGYVLT LSTREQHIRR DKATSNICTN AGLCSLAWTI HMTLLGEKGL TQLARLNHET 

       370        380        390        400        410        420 
ACELADALSA VPGVELVNET FFNEFTILLP KNADQVVNDL ARFGVLGGVP ASRLYPGRFE 

       430        440 
NYLIIAATET NTPEDIAVFA KALAGVL 

« Hide

References

[1]"Complete sequence of Maricaulis maris MCS10."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCS10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000449 Genomic DNA. Translation: ABI66501.1.
RefSeqYP_757439.1. NC_008347.1.

3D structure databases

ProteinModelPortalQ0AMJ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING394221.Mmar10_2209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI66501; ABI66501; Mmar10_2209.
GeneID4284978.
KEGGmmr:Mmar10_2209.
PATRIC22452596. VBIMarMar77530_2268.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMALPMHASE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycMMAR394221:GHNB-2258-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_MARMM
AccessionPrimary (citable) accession number: Q0AMJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families