Q0AMJ2 (GCSPA_MARMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Mmar10_2209

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00712
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045667

Sequences

	Sequence		Length	Mass (Da)
	Q0AMJ2 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 6C3833CB7510CA34	FASTA	447	48,030
	10 20 30 40 50 60 MRYLPHTDTD RKAMLDAIGV ASIDDLFTDV PEAARLDGLI DLPTKQTELQ VERALAAMSS 70 80 90 100 110 120 RNVAASHAPF FVGAGAYKHH VPATVDHLIQ RSEFLTAYTP YQPEISQGTL QTLFEFQTQV 130 140 150 160 170 180 ALLTGMDVAN ASMYDGSTAC AEAVMMAARV TRRTKAVMAG SVHPHYVEAS QTLAKYSDVS 190 200 210 220 230 240 ISVTDAAPAD LDAVIAEIDD TTACVVIQTP DIFGRLHDLR EVSRIAHEKG ALVIAVFTEA 250 260 270 280 290 300 VSLGLVEAPG HMGADIAVGE GQSIGVGLNF GGPYVGLFAC KDDRRFIRQM PGRLAGETID 310 320 330 340 350 360 ADGRRGYVLT LSTREQHIRR DKATSNICTN AGLCSLAWTI HMTLLGEKGL TQLARLNHET 370 380 390 400 410 420 ACELADALSA VPGVELVNET FFNEFTILLP KNADQVVNDL ARFGVLGGVP ASRLYPGRFE 430 440 NYLIIAATET NTPEDIAVFA KALAGVL

References

[1]

"Complete sequence of Maricaulis maris MCS10." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MCS10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000449 Genomic DNA. Translation: ABI66501.1.
RefSeq	YP_757439.1. NC_008347.1.
3D structure databases
ProteinModelPortal	Q0AMJ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AMJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4284978.
GenomeReviews	Gene locus Mmar10_2209 in contig CP000449_GR.
KEGG	mmr:Mmar10_2209.
NMPDR	fig|394221.5.peg.2170.
PATRIC	22452596. VBIMarMar77530_2268.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HBG288345.
OMA	VANASMY.
ProtClustDB	PRK00451.
Enzyme and pathway databases
BioCyc	MMAR394221:MMAR10_2209-MONOMER.
Family and domain databases
HAMAP	MF_00712. GcvPA. [Tree]
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KO	K00282.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSPA_MARMM

Accession

Primary (citable) accession number: Q0AMJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program