Reviewed, UniProtKB/Swiss-Prot Q0ALW1 (SAHH_MARMM)

Names and origin

Protein names

Recommended name:
    Adenosylhomocysteinase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
      Short name=AdoHcyase

Gene names

Name:	ahcY
Ordered Locus Names:	Mmar10_2440

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563
Cofactor	Binds 1 NAD per subunit By similarity.
Pathway	Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Adenosylhomocysteinase HAMAP MF_00563		PRO_1000061127
Regions
	Region	222 – 387	166	NAD binding By similarity
Sites
	Binding site	60	1	Substrate By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	195	1	Substrate By similarity
	Binding site	225	1	Substrate By similarity
	Binding site	229	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0ALW1-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 132FEE516538AE35	FASTA	469	51,834
	10 20 30 40 50 60 MTQFAADKPY IVKDMSLAKW GRIEFDMAEI EMPGLMALRE EYKDSQPLKG ARIAGSLHMT 70 80 90 100 110 120 VQTAILIETL TALGAEVRWA SCNIFSTQDH AAAAIAETGV PVFATKGETL EEYWDYADAI 130 140 150 160 170 180 FHWPDGETAN MILDDGGDAT MYLILGEKAE NDPSVLNHPK SEEETFLFAQ IKKRIAATPG 190 200 210 220 230 240 WFAKAKAAIQ GVSEETTTGV MRLYQMQKRG ELPFPAINVN DSVTKSKFDN RYGCRESLVD 250 260 270 280 290 300 AIRRGTDVMM AGKKALVFGY GDVGKGSAES LAGAGARVYV TEIDPICALQ ACMDGFEVVR 310 320 330 340 350 360 AEDVIGEMDI FVTATGNKDI LTVDHMRAMK DMAIVCNIGH FDNEIQVESL KNYQWTNVKP 370 380 390 400 410 420 QVDLVNFPEG HRIILLSEGR LVNLGNATGH PSFVMSASFT NQTLAQIELW TKGENYTNEV 430 440 450 460 YILPKHLDEK VAALHLDKLG AKLTVLSDEQ ADYIGVPQHG PFKAEHYRY

References

[1]

"Complete sequence of Maricaulis maris MCS10." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000449 Genomic DNA. Translation: ABI66732.1.
RefSeq	YP_757670.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4285422.
GenomeReviews	Gene locus Mmar10_2440 in contig CP000449_GR.
KEGG	mmr:Mmar10_2440.
NMPDR	fig|394221.5.peg.2393.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0ALW1.
OMA	Q0ALW1. HMRAMKD.
Family and domain databases
HAMAP	MF_00563. [Tree]
InterPro	IPR000043. Ad_hcy_hydrolase. IPR015878. Ado_hCys_hydrolase_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.1480. Ad_hcy_hydrolase. 1 hit.
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMs	TIGR00936. ahcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH_MARMM

Accession

Primary (citable) accession number: Q0ALW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)