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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Binding sitei225SubstrateUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Binding sitei230NADUniRule annotation1
Binding sitei282NADUniRule annotation1
Binding sitei317NADUniRule annotation1
Binding sitei383NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi196 – 198NADUniRule annotation3
Nucleotide bindingi259 – 264NADUniRule annotation6
Nucleotide bindingi338 – 340NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Mmar10_2440
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
Proteomesi
  • UP000001964 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000611271 – 469AdenosylhomocysteinaseAdd BLAST469

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_2440.

Structurei

3D structure databases

ProteinModelPortaliQ0ALW1.
SMRiQ0ALW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0ALW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQFAADKPY IVKDMSLAKW GRIEFDMAEI EMPGLMALRE EYKDSQPLKG
60 70 80 90 100
ARIAGSLHMT VQTAILIETL TALGAEVRWA SCNIFSTQDH AAAAIAETGV
110 120 130 140 150
PVFATKGETL EEYWDYADAI FHWPDGETAN MILDDGGDAT MYLILGEKAE
160 170 180 190 200
NDPSVLNHPK SEEETFLFAQ IKKRIAATPG WFAKAKAAIQ GVSEETTTGV
210 220 230 240 250
MRLYQMQKRG ELPFPAINVN DSVTKSKFDN RYGCRESLVD AIRRGTDVMM
260 270 280 290 300
AGKKALVFGY GDVGKGSAES LAGAGARVYV TEIDPICALQ ACMDGFEVVR
310 320 330 340 350
AEDVIGEMDI FVTATGNKDI LTVDHMRAMK DMAIVCNIGH FDNEIQVESL
360 370 380 390 400
KNYQWTNVKP QVDLVNFPEG HRIILLSEGR LVNLGNATGH PSFVMSASFT
410 420 430 440 450
NQTLAQIELW TKGENYTNEV YILPKHLDEK VAALHLDKLG AKLTVLSDEQ
460
ADYIGVPQHG PFKAEHYRY
Length:469
Mass (Da):51,834
Last modified:October 17, 2006 - v1
Checksum:i132FEE516538AE35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000449 Genomic DNA. Translation: ABI66732.1.
RefSeqiWP_011644377.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI66732; ABI66732; Mmar10_2440.
KEGGimmr:Mmar10_2440.

Similar proteinsi

Entry informationi

Entry nameiSAHH_MARMM
AccessioniPrimary (citable) accession number: Q0ALW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 17, 2006
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families