Q0AL71 (KATG_MARMM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Catalase-peroxidase
Short name=CP
EC=1.11.1.21

Alternative name(s):
Peroxidase/catalase

Gene names

Name:	katG
Ordered Locus Names:	Mmar10_2686

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	724 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961
Catalytic activity	Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961 2 H2O2 = O2 + 2 H2O. HAMAP MF_01961
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Homodimer or homotetramer By similarity. HAMAP MF_01961
Post-translational modification	The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961
Sequence similarities	Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	catalase activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 724	724	Catalase-peroxidase HAMAP MF_01961		PRO_0000354827
Sites
	Active site	99	1	Proton acceptor By similarity
	Metal binding	267	1	Iron (heme axial ligand) By similarity
	Site	95	1	Transition state stabilizer By similarity
Amino acid modifications
	Cross-link	98 ↔ 226		Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252) By similarity
	Cross-link	226 ↔ 252		Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0AL71 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 8E889846A5B0CCB0	FASTA	724	79,054
	10 20 30 40 50 60 MDGNNSNSQG KCPVMHGGNT ASEGDVMAWW PRALNLEILH QKDTKPNPMG DGPSYHEALK 70 80 90 100 110 120 SLDFDALKTD MHALLTDSQD WWPADYGHYG GLMIRLAWHS AGSYRLADGR GGGGSGNIRF 130 140 150 160 170 180 APLNSWPDNG NLDKARRLLW PLKKKYGNKI SWADLILLAG TIAYENMGLK TFGFGFGRED 190 200 210 220 230 240 IWGPEIDTYW GAEKEWLAPS DTRYEDVAKP DTMENPLAAV QMGLIYVNPE GVNGKPDPLK 250 260 270 280 290 300 TAAQVRTTFA RMAMNDEETA ALTAGGHTVG KTHGNGDAGA LGPEPEGAEL ENQGFGWVNP 310 320 330 340 350 360 NLGGKASNAV TSGLEGAWTT NPTQFDMGYF ELLFGYEWEL KKSPAGAQQW QPINIKPEHM 370 380 390 400 410 420 PVDASDPSQR RMPIMTDADM AMKMDPAYRA ICEKFMADPA YFKDTFARAW FKLTHRDMGP 430 440 450 460 470 480 KDCYFGPDVP SEELVWQDPV PAGPTGYDVA RVKSAIAASG LSIAEMVATA WDSARTFRGS 490 500 510 520 530 540 DKRGGANGAR IRLAPQKDWD GNEPDRLAKV LGVLEPIARD AGASLADVIV LAGNVGIEQA 550 560 570 580 590 600 ARAAGHDVAV PFSPGRGDAT DAMTDAESFD VLEPLADGYR NWQKADYVVS AEEMLLDRTQ 610 620 630 640 650 660 LLGLTAPEMT VLVGGMRVLG TNYGGTKHGV FTDREGALTT DFFVNLTDMA YSWVPVDRRT 670 680 690 700 710 720 YEIRDRKTGK ARWTATRADL VFGSNSILRA YAEVYAQDDN AGKFVADFVA AWTKVMNADR FDLA

References

[1]

"Complete sequence of Maricaulis maris MCS10." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MCS10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000449 Genomic DNA. Translation: ABI66972.1.
RefSeq	YP_757910.1. NC_008347.1.
3D structure databases
ProteinModelPortal	Q0AL71.
SMR	Q0AL71. Positions 29-723.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AL71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4286138.
GenomeReviews	Gene locus Mmar10_2686 in contig CP000449_GR.
KEGG	mmr:Mmar10_2686.
NMPDR	fig|394221.5.peg.2626.
PATRIC	22453584. VBIMarMar77530_2759.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0376.
HOGENOM	HBG285610.
OMA	WPNALNL.
PhylomeDB	Q0AL71.
ProtClustDB	PRK15061.
Enzyme and pathway databases
BioCyc	MMAR394221:MMAR10_2686-MONOMER.
Family and domain databases
HAMAP	MF_01961. Catal-peroxid. [Tree]
InterPro	IPR000763. Catalase_peroxidase. IPR010255. Haem_peroxidase. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. [Graphical view]
KO	K03782.
Pfam	PF00141. peroxidase. 2 hits. [Graphical view]
PRINTS	PR00460. BPEROXIDASE. PR00458. PEROXIDASE.
SUPFAM	SSF48113. Peroxidase_super. 2 hits.
TIGRFAMs	TIGR00198. Cat_per_HPI. 1 hit.
PROSITE	PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KATG_MARMM

Accession

Primary (citable) accession number: Q0AL71

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program