Reviewed, UniProtKB/Swiss-Prot Q0AKM4 (AHPD_MARMM)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	Mmar10_2888

Organism

Maricaulis maris (strain MCS10) [Complete proteome] [HAMAP]

Taxonomic identifier

394221 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Maricaulis

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359493
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0AKM4-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 047C649DDA1E6A6B	FASTA	173	18,569
	10 20 30 40 50 60 MSIDALKNEL PEYAKDLKLN LSSLGRETEL DDQKKWGTFL ASAHAVGEPK TLAAIKAEAE 70 80 90 100 110 120 TRLSDEALTA AKAASAIMGM NNVYYRFVHL SKNKEYATLP AKLRMNILAN PGVDKADFEL 130 140 150 160 170 WSLAVSAING CGLCIDSHEA ELRKHGLTTT QVQAAVRIAA TVNAIAAVLA AES

References

[1]

"Complete sequence of Maricaulis maris MCS10." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P., Stephens C., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000449 Genomic DNA. Translation: ABI67169.1.
RefSeq	YP_758107.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AKM4.
Protein family/group databases
PeroxiBase	4630. MmaAhpD.
Genome annotation databases
GeneID	4286318.
GenomeReviews	Gene locus Mmar10_2888 in contig CP000449_GR.
KEGG	mmr:Mmar10_2888.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0AKM4.
OMA	MAMNNVY.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_MARMM

Accession

Primary (citable) accession number: Q0AKM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	October 17, 2006
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)