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Q0AKF5

- SYL_MARMM

UniProt

Q0AKF5 - SYL_MARMM

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Protein
Leucine--tRNA ligase
Gene
leuS, Mmar10_2957
Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei628 – 6281ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-3011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mmar10_2957
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligaseUniRule annotation
PRO_1000009368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_2957.

Structurei

3D structure databases

ProteinModelPortaliQ0AKF5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionUniRule annotation
Add
BLAST
Motifi625 – 6295"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AKF5-1 [UniParc]FASTAAdd to Basket

« Hide

MTRYNPREAE PKWQSAWDAC DAFKAIGPSA SNNKPKYYVL EMFPYPSGRI    50
HVGHSRNYTM GDVVARYKRA RGFDVLHPMG WDAFGLPAEN AARDRGVHPG 100
AWTHDNIDAM RGQLQRLGLA LDWSREIATC DPSYYRHQQA IFLRLMERGL 150
LHRKTAKVNW DPVDQTVLAN EQVIDGRGWR SGALVVQREL DQWFFKITEY 200
ADELTDALEE LDRWPDKVRT MQSNWIGRSR GAEVSFPLTD SGLAEQFGAT 250
IDVFTTRPDT LFGASFLALA PDHPIVKALA ADDPEIDRFM HECARMGTTA 300
EEIEKAPKRG VDLGITVRHP FDENWELPVW SANFVLSGYG TGAIFGSPAG 350
DQRDLDFARK YDLAVQPVVL PPEASADTHV IEDEAYTGPG TSYNSRFLDG 400
LSTADALERA ITELEARKLG KGATSYRLRD WLVSRQRYWG CPIPVIHCAD 450
CGVVPVPEDQ LPVVLPEDVT FDHPSNPLER HPTWKNADCP KCGKAGRRET 500
DTLDTFVCSS WYFLRFTSPW SEDTPFLASD AEHWMPVDQY VGGIEHAILH 550
LLYARFFTRA LNDAGLMNMK SGEPFAGLFT QGMVTHETYK SADGKWLSPE 600
EVDLRKDGAV EMSTGKPVSV GAIEKMSKSK KNVVDLDAFI ESYGADAVRW 650
FVLSDSPPER DVEYTDSGVE GVWRFVQRLW STVTSLPEGA PGPLTVAADA 700
SGPALEIRRA AHKALHAVTD AIEGFRFNSA VAQVHDLVNV LRKYVPSDDA 750
GIAAKTEALG ILARIIAPFV PHLAEECWEH LGGEGLVIDA AWPEADPALL 800
VEDSVTLPVQ VNGKRRTEVT APKGAAQDVV QEMVMADQTV QRALEGLTVR 850
KVIVVPDRIV NIVAG 865
Length:865
Mass (Da):95,991
Last modified:October 17, 2006 - v1
Checksum:iBD003E6FD3A8A8E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI67238.1.
RefSeqiYP_758176.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI67238; ABI67238; Mmar10_2957.
GeneIDi4286264.
KEGGimmr:Mmar10_2957.
PATRICi22454144. VBIMarMar77530_3037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI67238.1 .
RefSeqi YP_758176.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0AKF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_2957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI67238 ; ABI67238 ; Mmar10_2957 .
GeneIDi 4286264.
KEGGi mmr:Mmar10_2957.
PATRICi 22454144. VBIMarMar77530_3037.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MMAR394221:GHNB-3011-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiSYL_MARMM
AccessioniPrimary (citable) accession number: Q0AKF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi