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Q0AKF5

- SYL_MARMM

UniProt

Q0AKF5 - SYL_MARMM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei628 – 6281ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-3011-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mmar10_2957
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligasePRO_1000009368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_2957.

Structurei

3D structure databases

ProteinModelPortaliQ0AKF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionAdd
BLAST
Motifi625 – 6295"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AKF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRYNPREAE PKWQSAWDAC DAFKAIGPSA SNNKPKYYVL EMFPYPSGRI
60 70 80 90 100
HVGHSRNYTM GDVVARYKRA RGFDVLHPMG WDAFGLPAEN AARDRGVHPG
110 120 130 140 150
AWTHDNIDAM RGQLQRLGLA LDWSREIATC DPSYYRHQQA IFLRLMERGL
160 170 180 190 200
LHRKTAKVNW DPVDQTVLAN EQVIDGRGWR SGALVVQREL DQWFFKITEY
210 220 230 240 250
ADELTDALEE LDRWPDKVRT MQSNWIGRSR GAEVSFPLTD SGLAEQFGAT
260 270 280 290 300
IDVFTTRPDT LFGASFLALA PDHPIVKALA ADDPEIDRFM HECARMGTTA
310 320 330 340 350
EEIEKAPKRG VDLGITVRHP FDENWELPVW SANFVLSGYG TGAIFGSPAG
360 370 380 390 400
DQRDLDFARK YDLAVQPVVL PPEASADTHV IEDEAYTGPG TSYNSRFLDG
410 420 430 440 450
LSTADALERA ITELEARKLG KGATSYRLRD WLVSRQRYWG CPIPVIHCAD
460 470 480 490 500
CGVVPVPEDQ LPVVLPEDVT FDHPSNPLER HPTWKNADCP KCGKAGRRET
510 520 530 540 550
DTLDTFVCSS WYFLRFTSPW SEDTPFLASD AEHWMPVDQY VGGIEHAILH
560 570 580 590 600
LLYARFFTRA LNDAGLMNMK SGEPFAGLFT QGMVTHETYK SADGKWLSPE
610 620 630 640 650
EVDLRKDGAV EMSTGKPVSV GAIEKMSKSK KNVVDLDAFI ESYGADAVRW
660 670 680 690 700
FVLSDSPPER DVEYTDSGVE GVWRFVQRLW STVTSLPEGA PGPLTVAADA
710 720 730 740 750
SGPALEIRRA AHKALHAVTD AIEGFRFNSA VAQVHDLVNV LRKYVPSDDA
760 770 780 790 800
GIAAKTEALG ILARIIAPFV PHLAEECWEH LGGEGLVIDA AWPEADPALL
810 820 830 840 850
VEDSVTLPVQ VNGKRRTEVT APKGAAQDVV QEMVMADQTV QRALEGLTVR
860
KVIVVPDRIV NIVAG
Length:865
Mass (Da):95,991
Last modified:October 17, 2006 - v1
Checksum:iBD003E6FD3A8A8E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000449 Genomic DNA. Translation: ABI67238.1.
RefSeqiYP_758176.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI67238; ABI67238; Mmar10_2957.
GeneIDi4286264.
KEGGimmr:Mmar10_2957.
PATRICi22454144. VBIMarMar77530_3037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000449 Genomic DNA. Translation: ABI67238.1 .
RefSeqi YP_758176.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0AKF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_2957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI67238 ; ABI67238 ; Mmar10_2957 .
GeneIDi 4286264.
KEGGi mmr:Mmar10_2957.
PATRICi 22454144. VBIMarMar77530_3037.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MMAR394221:GHNB-3011-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiSYL_MARMM
AccessioniPrimary (citable) accession number: Q0AKF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3