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Q0AK62

- PNP_MARMM

UniProt

Q0AK62 - PNP_MARMM

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Mmar10_3050
Organism
Maricaulis maris (strain MCS10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMMAR394221:GHNB-3104-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Mmar10_3050
OrganismiMaricaulis maris (strain MCS10)
Taxonomic identifieri394221 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeMaricaulis
ProteomesiUP000001964: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000329708Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi394221.Mmar10_3050.

Structurei

3D structure databases

ProteinModelPortaliQ0AK62.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHAdd
BLAST
Domaini624 – 69269S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AK62-1 [UniParc]FASTAAdd to Basket

« Hide

MFDIQKETIE WAGRPLTIET GRVARQADGA VMVSYGETTV LATAVGVKQA    50
KPGVDFFPLT VNYQEKYFAA GKIPGGFFKR EGRPTDKETL TSRLIDRPIR 100
PLFVKGFKNE VQVMLTVLSH DLENDPDIVG MIGASAALVL SGLPFMGPIG 150
AARVGYKDGE YVINPPCDEM DDSELDLVVA GTQDAVMMVE SEAKELSEEV 200
MLGAVMAGHK AFQPVIDMII KLAERAAKEP WDYAPADHSA EEAKVRDLIG 250
DDLAAAYTIV DKTERYKAVG AAKDKAVEAL LQTEERPDGI DMTTLKDVMK 300
AVESSIVRGG IIKTGKRIDG RSLDQVRSIV SEAGILPRTH GSALFTRGET 350
QALVVATLGT GEDEQFIDAL TGTYKERFML HYNFPPYSVG ETSFRLAPGR 400
REIGHGKLAW RAVKAVLPTK EDFPYTIRLV SEITESNGSS SMATVCGASL 450
SMMDAGVPIT RPVSGIAMGL IKDPEGIAVL SDILGDEDHL GDMDFKVAGT 500
TEGVTSLQMD IKIAGIDEEI MKTALAQASG GRLHILEEMG KALGEARTEL 550
GEFAPRIETI TIPTDKIRDV IGSGGKVIRE IVETTGAKVD VNDDGVIKVS 600
SSDGASIKAA LDWIHGLTAE PEEGQIYKGK VVKVMDFGAF VNFFGPKDGL 650
VHVSQLKAER VNHPSDVVKE GQEVYVKLLG FDDRGKVRLS MKIIDQETGE 700
EIKKEQEDAE 710
Length:710
Mass (Da):76,823
Last modified:October 17, 2006 - v1
Checksum:iC5E9DCBB467F9FD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI67331.1.
RefSeqiYP_758269.1. NC_008347.1.

Genome annotation databases

EnsemblBacteriaiABI67331; ABI67331; Mmar10_3050.
GeneIDi4284714.
KEGGimmr:Mmar10_3050.
PATRICi22454334. VBIMarMar77530_3132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000449 Genomic DNA. Translation: ABI67331.1 .
RefSeqi YP_758269.1. NC_008347.1.

3D structure databases

ProteinModelPortali Q0AK62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 394221.Mmar10_3050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI67331 ; ABI67331 ; Mmar10_3050 .
GeneIDi 4284714.
KEGGi mmr:Mmar10_3050.
PATRICi 22454334. VBIMarMar77530_3132.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MMAR394221:GHNB-3104-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS10.

Entry informationi

Entry nameiPNP_MARMM
AccessioniPrimary (citable) accession number: Q0AK62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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