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Q0AJJ0 (UPPP_NITEC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Neut_0195
OrganismNitrosomonas eutropha (strain C91) [Complete proteome] [HAMAP]
Taxonomic identifier335283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290737

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane253 – 27321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0AJJ0 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: BDAB712EDAC44BA9

FASTA27330,315
        10         20         30         40         50         60 
MDWLILIKAF LLGIVEGLTE FLPISSTGHL ILAGDLLDFN DDKAQVFTVA IQLGAILSVC 

        70         80         90        100        110        120 
WEYRARLINV ARGWGTRRAN RFVLNLCVAF LPAAILGLLF IKTIKYYLFH PLPVAIALVT 

       130        140        150        160        170        180 
GGVLILWAER REHRIEVENV DDMNWKHALK IGCAQCLALI PGTSRSGATI IGGLLSGLSR 

       190        200        210        220        230        240 
KAAAEFSFFL AIPIMFAATF YDVYKHREFL HSDDLGMFVV GSIAAFISAL IAIRGFIRYV 

       250        260        270 
SHHDFTLFAW YRIGFGLIVL LTAHFGLINW SAG 

« Hide

References

[1]"Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C91.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000450 Genomic DNA. Translation: ABI58481.1.
RefSeqYP_746446.1. NC_008344.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335283.Neut_0195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI58481; ABI58481; Neut_0195.
GeneID4272436.
KEGGnet:Neut_0195.
PATRIC22717314. VBINitEut7577_0341.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycNEUT335283:GHT6-198-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_NITEC
AccessionPrimary (citable) accession number: Q0AJJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families