Q0AHZ8 (ARGC_NITEC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Neut_0764

Organism

Nitrosomonas eutropha (strain C91) [Complete proteome] [HAMAP]

Taxonomic identifier

335283 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011024
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0AHZ8 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 25E0B4E8CB288462	FASTA	342	37,172
	10 20 30 40 50 60 MINVGIVGGT GYTGVELLRI LAQHPKAKLK VITSRQEAGT GVDDLFSSLR GQITLKFSDP 70 80 90 100 110 120 LKVDFGKCDV VFFATPNGIA MQQVSALLGS GIKVIDLSAD FRIKDVAEWE EWYGMSHTAP 130 140 150 160 170 180 ELVAEAVYGL PEVNREKIRN ARLIANPGCY PTAVQLGFIP LIEAGAVDEN HLIADTKSGV 190 200 210 220 230 240 SGAGRKAEIH TLYAEASDNF KSYAVAGHRH LPEIRQGLSE RSGKPIDLTF VPHLTPMIRG 250 260 270 280 290 300 IHATLYARLT RDVDLQALYE SRYANEPFVD VLPAGSHPET RSVRGSNFCR IAVHRPRNGD 310 320 330 340 TAVILSVTDN LVKGAAGQAV QNMNIMYGLP EKMGIQHIPL LP

References

[1]

"Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation." Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X. Environ. Microbiol. 9:2993-3007(2007) [PubMed: 17991028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C91.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000450 Genomic DNA. Translation: ABI59034.1.
RefSeq	YP_746999.1. NC_008344.1.
3D structure databases
ProteinModelPortal	Q0AHZ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AHZ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4272988.
GenomeReviews	Gene locus Neut_0764 in contig CP000450_GR.
KEGG	net:Neut_0764.
NMPDR	fig|335283.3.peg.2389.
PATRIC	22718631. VBINitEut7577_0985.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q0AHZ8.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	NEUT335283:NEUT_0764-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_NITEC

Accession

Primary (citable) accession number: Q0AHZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program