Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Nitrosomonas eutropha (strain C91)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Neut_1580), Pyruvate kinase (Neut_0979)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei87Proton donor/acceptorUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:Neut_0919Imported
OrganismiNitrosomonas eutropha (strain C91)Imported
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001966 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi335283.Neut_0919.

Structurei

3D structure databases

ProteinModelPortaliQ0AHK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 15Substrate bindingUniRule annotation8
Regioni21 – 22Substrate bindingUniRule annotation2
Regioni87 – 90Substrate bindingUniRule annotation4
Regioni114 – 115Substrate bindingUniRule annotation2
Regioni183 – 184Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DKJ. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiRMLPYWY.
OrthoDBiPOG091H03E2.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiView protein in InterPro
IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiView protein in Pfam
PF00300. His_Phos_1. 1 hit.
SMARTiView protein in SMART
SM00855. PGAM. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiView protein in PROSITE
PS00175. PG_MUTASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0AHK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLVLLRHG ESTWNQENRF TGWTDVDLTP KGFKEARNAG RLLRENGFTF
60 70 80 90 100
DIAHTSLLKR AIRTLWIALD EMDQMWTPIE LNWRLNERHY GALQGLNKAE
110 120 130 140 150
TAKEYGDEQV LIWRRSYDTR PPSITTDDKR YPGFDMRYRG LPSGDIPVTE
160 170 180 190 200
SLKDTVARFL PYWNQSIAPQ IKAEKKVIIT AHGNSLRALI KHLDNISDQD
210 220 230 240
ILNCNIPTGI PLVYELDNNL KPLTNYYLGN DSVIGEAISA VANQDKAGA
Length:249
Mass (Da):28,427
Last modified:October 17, 2006 - v1
Checksum:i5FECC2CB6827FC52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000450 Genomic DNA. Translation: ABI59179.1.
RefSeqiWP_011634003.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaiABI59179; ABI59179; Neut_0919.
KEGGinet:Neut_0919.

Similar proteinsi

Entry informationi

Entry nameiQ0AHK3_NITEC
AccessioniPrimary (citable) accession number: Q0AHK3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported