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Q0AG57

- SYL_NITEC

UniProt

Q0AG57 - SYL_NITEC

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Protein
Leucine--tRNA ligase
Gene
leuS, Neut_1429
Organism
Nitrosomonas eutropha (strain C91)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNEUT335283:GHT6-1456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Neut_1429
OrganismiNitrosomonas eutropha (strain C91)
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001966: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 868868Leucine--tRNA ligaseUniRule annotation
PRO_1000009378Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335283.Neut_1429.

Structurei

3D structure databases

ProteinModelPortaliQ0AG57.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi624 – 6285"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AG57-1 [UniParc]FASTAAdd to Basket

« Hide

MQEKYHPQEI EQQARQSWQE TGIFNTTEIP DKPKYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VLSRYRRMQG YNVMQPMGWD AFGLPAENAA IQKGVPPAKW 100
TYDNIAYMRS QLQSLGLAID WKRELATCDP EYYRWNQWLF LRMLEKGIAY 150
QKTQVVNWDP VDQTVLANEQ VIDGCGWRTG AVVEKREIPG YYLAITRYAD 200
ELLAGLENLP GWPERVKAMQ ANWIGKSYGV DIIFSPDIAS GMPQALKVFT 250
TRADTLMGAT YVAVAAEHPV ALYAAQNQPK LAAFIESCRQ GATMEAELAL 300
QEKKGMATGL YVLHPLTGER LPVWVANYVL MSYGEGAVMA VPAHDERDFD 350
FARQYALPIR PVIKPEDGEL PAPLAQAFTG YGVTFDSGEF SSLKSMDAVD 400
AIATKLKLEE QGEKRVRYRL RDWGISRQRY WGCPIPLVHC DQCGVVPVPD 450
DQLPVTLPED LVPDGSGNPL TKTPSFYECT CPRCGQQAHR ETDTMDTFVD 500
SSWYFIRYAC QDQQAAMTDQ RANYWLPVDQ YIGGIEHAIL HLLYSRFWSK 550
VMRDLGLVSF DEPFANLLTQ GMVLNEIFFR KTGNGRIQYF NPVEVDVQYD 600
AEGKKIGAVL QADGQPVESG GIGTMSKSKN NGIDPQEIIE QYGADTARLF 650
MMFASPPTQT LEWSDAGVEG AFRFLKRLWR QVYLHRQQGS DMSATDAIPH 700
LEYPADLRDL RCQLHQTIVK VTDDLERRHT FNTAIAAVME LMNKLAGVQD 750
ISPAARQLMQ EALENSVLLL SPIVPHICHI LWRELRPGTE LLDQPWPQAD 800
EQALIQDEIE IVVQINGKLR GQIRIAREAD QATIERIALE HEHVQRNIAG 850
QPIRKVVIVP GRLVNIVV 868
Length:868
Mass (Da):98,169
Last modified:October 17, 2006 - v1
Checksum:i91196E00FCE9842F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI59675.1.
RefSeqiYP_747640.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaiABI59675; ABI59675; Neut_1429.
GeneIDi4272733.
KEGGinet:Neut_1429.
PATRICi22720221. VBINitEut7577_1770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI59675.1 .
RefSeqi YP_747640.1. NC_008344.1.

3D structure databases

ProteinModelPortali Q0AG57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335283.Neut_1429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI59675 ; ABI59675 ; Neut_1429 .
GeneIDi 4272733.
KEGGi net:Neut_1429.
PATRICi 22720221. VBINitEut7577_1770.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NEUT335283:GHT6-1456-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
    Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
    Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C91.

Entry informationi

Entry nameiSYL_NITEC
AccessioniPrimary (citable) accession number: Q0AG57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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