Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0AFY5 (GCH4_NITEC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Neut_1502
OrganismNitrosomonas eutropha (strain C91) [Complete proteome] [HAMAP]
Taxonomic identifier335283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289501

Sites

Site1541May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0AFY5 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 67BF8E58C7BE8E55

FASTA26730,454
        10         20         30         40         50         60 
MKKHTDQPIA DVQGSPDTRH IAIDRVGIKA IRHPVLVADK DGGSQHTVAQ FNMYVNLPHN 

        70         80         90        100        110        120 
FKGTHMSRFV EILNSHEREI SVESFEEILR SMVSRLESDS GHIEMTFPYF VNKSAPISGV 

       130        140        150        160        170        180 
KSLLDYEVTF IGEIKHGDQY GFTMKVIVPV TSLCPCSKKI SDYGAHNQRS HVTISVHTNS 

       190        200        210        220        230        240 
FVWIEDVIRI AEEQASCELF GLLKRPDEKY VTEKAYNNPK FVEDIVRDVA EILNHDDRID 

       250        260 
AYVVESENFE SIHNHSAYAL IERDKRK 

« Hide

References

[1]"Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C91.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000450 Genomic DNA. Translation: ABI59747.1.
RefSeqYP_747712.1. NC_008344.1.

3D structure databases

ProteinModelPortalQ0AFY5.
SMRQ0AFY5. Positions 20-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335283.Neut_1502.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI59747; ABI59747; Neut_1502.
GeneID4273855.
KEGGnet:Neut_1502.
PATRIC22720390. VBINitEut7577_1852.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycNEUT335283:GHT6-1531-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_NITEC
AccessionPrimary (citable) accession number: Q0AFY5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways