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Q0AFY5

- GCH4_NITEC

UniProt

Q0AFY5 - GCH4_NITEC

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Neut_1502
Organism
Nitrosomonas eutropha (strain C91)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciNEUT335283:GHT6-1531-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Neut_1502
OrganismiNitrosomonas eutropha (strain C91)
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267GTP cyclohydrolase FolE2UniRule annotationPRO_0000289501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335283.Neut_1502.

Structurei

3D structure databases

ProteinModelPortaliQ0AFY5.
SMRiQ0AFY5. Positions 20-265.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AFY5-1 [UniParc]FASTAAdd to Basket

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MKKHTDQPIA DVQGSPDTRH IAIDRVGIKA IRHPVLVADK DGGSQHTVAQ    50
FNMYVNLPHN FKGTHMSRFV EILNSHEREI SVESFEEILR SMVSRLESDS 100
GHIEMTFPYF VNKSAPISGV KSLLDYEVTF IGEIKHGDQY GFTMKVIVPV 150
TSLCPCSKKI SDYGAHNQRS HVTISVHTNS FVWIEDVIRI AEEQASCELF 200
GLLKRPDEKY VTEKAYNNPK FVEDIVRDVA EILNHDDRID AYVVESENFE 250
SIHNHSAYAL IERDKRK 267
Length:267
Mass (Da):30,454
Last modified:October 17, 2006 - v1
Checksum:i67BF8E58C7BE8E55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI59747.1.
RefSeqiYP_747712.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaiABI59747; ABI59747; Neut_1502.
GeneIDi4273855.
KEGGinet:Neut_1502.
PATRICi22720390. VBINitEut7577_1852.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI59747.1 .
RefSeqi YP_747712.1. NC_008344.1.

3D structure databases

ProteinModelPortali Q0AFY5.
SMRi Q0AFY5. Positions 20-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335283.Neut_1502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI59747 ; ABI59747 ; Neut_1502 .
GeneIDi 4273855.
KEGGi net:Neut_1502.
PATRICi 22720390. VBINitEut7577_1852.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci NEUT335283:GHT6-1531-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
    Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
    Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C91.

Entry informationi

Entry nameiGCH4_NITEC
AccessioniPrimary (citable) accession number: Q0AFY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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