argS

Functionⁱ

Catalytic activityⁱ

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functionⁱ

arginine-tRNA ligase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

arginyl-tRNA aminoacylation Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation) Alternative name(s): Arginyl-tRNA synthetaseUniRule annotation Short name: ArgRSUniRule annotation
Gene namesⁱ	Name:argSUniRule annotation Ordered Locus Names:Neut_1605
Organismⁱ	Nitrosomonas eutropha (strain C91)
Taxonomic identifierⁱ	335283 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas › Nitrosomonas eutropha
Proteomesⁱ	UP000001966 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00123

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000018076	1 – 586	Arginine--tRNA ligaseAdd BLAST		586

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	335283.Neut_1605.

STRINGⁱ

335283.Neut_1605.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0AFN4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	131 – 141	"HIGH" regionAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C75. Bacteria. COG0018. LUCA.
HOGENOMⁱ	HOG000247214.
KEGG Orthology (KO) More...KOⁱ	K01887.
OMAⁱ	NKPLHLG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01RF.

Family and domain databases

Gene3Dⁱ	1.10.730.10. 1 hit. 3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAPⁱ	MF_00123. Arg_tRNA_synth. 1 hit.
InterProⁱ	View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERⁱ	PTHR11956. PTHR11956. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 2 hits.
PRINTSⁱ	PR01038. TRNASYNTHARG.
SMARTⁱ	View protein in SMART SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit.
SUPFAMⁱ	SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit.
TIGRFAMsⁱ	TIGR00456. argS. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0AFN4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATTIPFDFR SHCVQLLAQA VKQVLPEETE IHIELQRPKQ MDHGDYSTNL 
        60         70         80         90        100
AMKLAKRLRR NPLELAKVLI GALPDSPYVG KTVVAGGGFV NFFLKKTAKQ 
       110        120        130        140        150
QFLLTVLQAA DSFGHSKLGA GKTIQIEFVS ANPTGPLHVG HGRGAAFGAS 
       160        170        180        190        200
LANIMAAAGY AVTREFYVND AGRQMDILAL STWLRYLDLC GIALPFPSNA 
       210        220        230        240        250
YQGRYVVDMA LEIHRIHGDR YAHYSDSPTQ QLAEINAKAA ADGEDEYLDN 
       260        270        280        290        300
LITAAKSILG EDYAYLHNFV LTEQLNDCRN DLMEFGVEFE NWFSEQSLFD 
       310        320        330        340        350
SGMVARAVQL LDDKKLLYRQ DGALWFQSTG FGDEKDRVVQ RENGQYTYFA 
       360        370        380        390        400
SDIAYHLSKY ERGFDYMLNI WGADHHGYIS RVKGAIEALS LDSDKLEIAL 
       410        420        430        440        450
VQFAVLYRDG NKISMSTRSG EFVTLRQLRQ EVGNDAARFF YVLRKSDQHL 
       460        470        480        490        500
DFDLDLAKSQ SNDNPVYYVQ YAHARICSVL EQWGGAVDIF GRAETELLTN 
       510        520        530        540        550
PAELVLLQKI IDFPDTIEAA AKEHAPHLIA FFLRELASEF HSYYNSTRFL 
       560        570        580 
IPDEALKIAR LALISAVCQV LSKGLSLLGV TSPRKM

Length:586

Mass (Da):65,632

Last modified:October 17, 2006 - v1

Checksum:ⁱBA3B6F4517BEB060

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000450 Genomic DNA. Translation: ABI59848.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011634654.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABI59848; ABI59848; Neut_1605.
KEGGⁱ	net:Neut_1605.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000450 Genomic DNA. Translation: ABI59848.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011634654.1. NC_008344.1.

3D structure databases

ProteinModelPortalⁱ	Q0AFN4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	335283.Neut_1605.

STRINGⁱ

335283.Neut_1605.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABI59848; ABI59848; Neut_1605.
KEGGⁱ	net:Neut_1605.

Phylogenomic databases

eggNOGⁱ	ENOG4105C75. Bacteria. COG0018. LUCA.
HOGENOMⁱ	HOG000247214.
KEGG Orthology (KO) More...KOⁱ	K01887.
OMAⁱ	NKPLHLG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01RF.

Family and domain databases

Gene3Dⁱ	1.10.730.10. 1 hit. 3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAPⁱ	MF_00123. Arg_tRNA_synth. 1 hit.
InterProⁱ	View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERⁱ	PTHR11956. PTHR11956. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 2 hits.
PRINTSⁱ	PR01038. TRNASYNTHARG.
SMARTⁱ	View protein in SMART SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit.
SUPFAMⁱ	SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit.
TIGRFAMsⁱ	TIGR00456. argS. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYR_NITEC
Accessionⁱ	Q0AFN4Primary (citable) accession number: Q0AFN4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	October 17, 2006
	Last modified:	June 7, 2017
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

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UniProtKB - Q0AFN4 (SYR_NITEC)

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Arginine--tRNA ligase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ