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Q0AFI1

- PYRC_NITEC

UniProt

Q0AFI1 - PYRC_NITEC

Protein

Dihydroorotase

Gene

pyrC

Organism
Nitrosomonas eutropha (strain C91)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi14 – 141Zinc 1; via tele nitrogenUniRule annotation
    Metal bindingi16 – 161Zinc 1; via tele nitrogenUniRule annotation
    Metal bindingi102 – 1021Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi102 – 1021Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi139 – 1391Zinc 2; via pros nitrogenUniRule annotation
    Metal bindingi177 – 1771Zinc 2; via tele nitrogenUniRule annotation
    Metal bindingi250 – 2501Zinc 1UniRule annotation

    GO - Molecular functioni

    1. dihydroorotase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. pyrimidine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciNEUT335283:GHT6-1692-MONOMER.
    UniPathwayiUPA00070; UER00117.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DihydroorotaseUniRule annotation (EC:3.5.2.3UniRule annotation)
    Short name:
    DHOaseUniRule annotation
    Gene namesi
    Name:pyrCUniRule annotation
    Ordered Locus Names:Neut_1659
    OrganismiNitrosomonas eutropha (strain C91)
    Taxonomic identifieri335283 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
    ProteomesiUP000001966: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345DihydroorotasePRO_1000024025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi335283.Neut_1659.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AFI1.
    SMRiQ0AFI1. Positions 2-345.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0418.
    HOGENOMiHOG000256259.
    KOiK01465.
    OMAiVAFEPLM.
    OrthoDBiEOG6TFCMH.

    Family and domain databases

    HAMAPiMF_00219. PyrC_type1.
    InterProiIPR006680. Amidohydro_1.
    IPR004721. DHOdimr.
    IPR002195. Dihydroorotase_CS.
    [Graphical view]
    PfamiPF01979. Amidohydro_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001237. DHOdimr. 1 hit.
    TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
    PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
    PS00483. DIHYDROOROTASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0AFI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNKLTFTRP DDWHLHLRDG KAMQSVLPDT ARRFARAMIM PNLKLPVVTT    50
    EQAAAYRARI LSALPQELVG QFEPLMTLYL TDTTTPEEIS RAKASGIVQA 100
    VKLYPAGATT HSDAGVTDID RCKATLAMME KLDMPLLVHG EVVDPAVDIF 150
    DREKIFIDRV LIPLLQRFPG LRVVFEHITT REAVEFVQSI SNRIAATITA 200
    HHLMLNRNAL FTGGLQPHHY CLPVLKREIH RQALVAAATS GHSRFFLGTD 250
    SAPHPLKDKE SACGCAGIYS AHAAIEFYAE IFEQAGRLDR LEAFASFYGP 300
    DFYGLPRNTD QISLSKESWQ IPGEVEFGGD RLVPLRAGEQ VCWRL 345
    Length:345
    Mass (Da):38,476
    Last modified:October 17, 2006 - v1
    Checksum:i0AD34C94361246F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000450 Genomic DNA. Translation: ABI59901.1.
    RefSeqiYP_747866.1. NC_008344.1.

    Genome annotation databases

    EnsemblBacteriaiABI59901; ABI59901; Neut_1659.
    GeneIDi4273812.
    KEGGinet:Neut_1659.
    PATRICi22720754. VBINitEut7577_2030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000450 Genomic DNA. Translation: ABI59901.1 .
    RefSeqi YP_747866.1. NC_008344.1.

    3D structure databases

    ProteinModelPortali Q0AFI1.
    SMRi Q0AFI1. Positions 2-345.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335283.Neut_1659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI59901 ; ABI59901 ; Neut_1659 .
    GeneIDi 4273812.
    KEGGi net:Neut_1659.
    PATRICi 22720754. VBINitEut7577_2030.

    Phylogenomic databases

    eggNOGi COG0418.
    HOGENOMi HOG000256259.
    KOi K01465.
    OMAi VAFEPLM.
    OrthoDBi EOG6TFCMH.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00117 .
    BioCyci NEUT335283:GHT6-1692-MONOMER.

    Family and domain databases

    HAMAPi MF_00219. PyrC_type1.
    InterProi IPR006680. Amidohydro_1.
    IPR004721. DHOdimr.
    IPR002195. Dihydroorotase_CS.
    [Graphical view ]
    Pfami PF01979. Amidohydro_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001237. DHOdimr. 1 hit.
    TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
    PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
    PS00483. DIHYDROOROTASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
      Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
      Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C91.

    Entry informationi

    Entry nameiPYRC_NITEC
    AccessioniPrimary (citable) accession number: Q0AFI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3