SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0AF74

- NAGZ_NITEC

UniProt

Q0AF74 - NAGZ_NITEC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta-hexosaminidase
Gene
nagZ, Neut_1774
Organism
Nitrosomonas eutropha (strain C91)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641Substrate By similarity
Binding sitei72 – 721Substrate By similarity
Binding sitei138 – 1381Substrate By similarity
Sitei179 – 1791Important for catalytic activity By similarity
Active sitei181 – 1811Proton donor/acceptor By similarity
Active sitei252 – 2521Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNEUT335283:GHT6-1809-MONOMER.
RETL1328306-WGS:GSTH-1869-MONOMER.
UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:Neut_1774
OrganismiNitrosomonas eutropha (strain C91)
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001966: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Beta-hexosaminidaseUniRule annotation
PRO_1000005658Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi335283.Neut_1774.

Structurei

3D structure databases

ProteinModelPortaliQ0AF74.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 1692Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000248526.
KOiK01207.
OMAiICNQPDE.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0AF74-1 [UniParc]FASTAAdd to Basket

« Hide

MFLGPLMLDI AGTTLTETDR VQLSHPLVGG VILFARNYES PAQLSELTAS    50
IHALRSPPLL IAVDQEGGRV QRFRDGFTRL PPMRTLGEIQ DRNPDLSLHL 100
ARQIGYVLAA ELKACGVDVS FTPVLDLDCE QSSVIGDRAF YREPQVVAEL 150
AHALMSGLQS VGMVAVGKHF PGHGAIQADT HVETAIDSRN YTDIEKKDLT 200
PFRRMIDTGL SGIMAAHVIY PAIDPNPAGF SSKWLQDILR NELGFRGCIF 250
SDDLCMQAAR NYGSITHRAE QALQAGCNMV LICNDPDSAD ELLTSLQWEF 300
SAVDTARLEH MRGQQTVHSM AQLHEMERFI RATEEISRIS LANISVSV 348
Length:348
Mass (Da):38,310
Last modified:October 17, 2006 - v1
Checksum:iBFAB788AE8702C38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI60008.1.
RefSeqiWP_011634814.1. NC_008344.1.
YP_747973.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaiABI60008; ABI60008; Neut_1774.
GeneIDi4273123.
KEGGinet:Neut_1774.
PATRICi22721030. VBINitEut7577_2165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI60008.1 .
RefSeqi WP_011634814.1. NC_008344.1.
YP_747973.1. NC_008344.1.

3D structure databases

ProteinModelPortali Q0AF74.
ModBasei Search...

Protein-protein interaction databases

STRINGi 335283.Neut_1774.

Protein family/group databases

CAZyi GH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI60008 ; ABI60008 ; Neut_1774 .
GeneIDi 4273123.
KEGGi net:Neut_1774.
PATRICi 22721030. VBINitEut7577_2165.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000248526.
KOi K01207.
OMAi ICNQPDE.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci NEUT335283:GHT6-1809-MONOMER.
RETL1328306-WGS:GSTH-1869-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
    Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
    Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C91.

Entry informationi

Entry nameiNAGZ_NITEC
AccessioniPrimary (citable) accession number: Q0AF74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi