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Q0AEQ0

- GCSPB_NITEC

UniProt

Q0AEQ0 - GCSPB_NITEC

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Nitrosomonas eutropha (strain C91)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNEUT335283:GHT6-1991-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Neut_1952
OrganismiNitrosomonas eutropha (strain C91)
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000045699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi335283.Neut_1952.

Structurei

3D structure databases

ProteinModelPortaliQ0AEQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiLGETPWD.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0AEQ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIFEHSRKN RLNYSQAPAT RPAKNNIPDN LKRKSAPLLP EVSEMDTVRH
60 70 80 90 100
YTRLSQKNFS IDTEFYPLGS CTMKYNPRAC NALAMLPQFL SRHPLAPEDT
110 120 130 140 150
GQGFLACMYE LQEILKDVTG MSAVSLTSMA GAQGELIGIT MIRAYHEARG
160 170 180 190 200
DTERTEIIIP DAAHGTNPAT AVMCGYKVIE IPTDRDGDVD MEALKAAVSP
210 220 230 240 250
RTAGLMLTNP STLGVFEKKV AEMSRVVHEA GGLLYYDGAN LNAVLGKVKP
260 270 280 290 300
GDMGFDVIHM NLHKTFSTPH GGGGPGAAPV GVADCLLPYL PIPIVAHEQG
310 320 330 340 350
VYRWLTEKDR PQSIGRLSAH MGNAGVLLRA YIYVRLLGAE GMFRIAEYAT
360 370 380 390 400
LNANYLLAEL RKLGFEIAYP SRRASHEFIV TMKEIKDKTG VTAMHLAKRL
410 420 430 440 450
LDKGFHAPTV YFPLLVPECL LIEPAETESK ETLDRFVVAM KEILDEIDTQ
460 470 480
PEMVKTAPHN MPLRKIDDVK AARELDLVWN PAG
Length:483
Mass (Da):53,271
Last modified:October 17, 2006 - v1
Checksum:iF60634E9959D10CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000450 Genomic DNA. Translation: ABI60182.1.
RefSeqiWP_011634983.1. NC_008344.1.
YP_748147.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaiABI60182; ABI60182; Neut_1952.
GeneIDi4273339.
KEGGinet:Neut_1952.
PATRICi22721458. VBINitEut7577_2375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000450 Genomic DNA. Translation: ABI60182.1 .
RefSeqi WP_011634983.1. NC_008344.1.
YP_748147.1. NC_008344.1.

3D structure databases

ProteinModelPortali Q0AEQ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335283.Neut_1952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI60182 ; ABI60182 ; Neut_1952 .
GeneIDi 4273339.
KEGGi net:Neut_1952.
PATRICi 22721458. VBINitEut7577_2375.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi LGETPWD.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NEUT335283:GHT6-1991-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
    Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
    Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C91.

Entry informationi

Entry nameiGCSPB_NITEC
AccessioniPrimary (citable) accession number: Q0AEQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3