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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Nitrosomonas eutropha (strain C91)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Neut_1953
OrganismiNitrosomonas eutropha (strain C91)
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001966 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456701 – 451Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST451

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi335283.Neut_1953

Structurei

3D structure databases

ProteinModelPortaliQ0AEP9
SMRiQ0AEP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q0AEP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIPHTEED VTEMLASIGA TSIDELFDEI PAELKNGKLT QVPTGMSEME
60 70 80 90 100
ISRLMYERAQ KDGFYLSFIG AGAYEHHIPA AVWQITTRGE FYSSYTPYQA
110 120 130 140 150
EASQGTLQLL YEYQTMMASL AGMDVSNASL YDGASALAEA ALMAVRQHKS
160 170 180 190 200
SRRILVPQTV HPIYRSVVRT IVRNQAIEVV EVPYDPATGQ VSIDQLDQFA
210 220 230 240 250
QEEFAALIIP QPNFFGVLEQ VDTLADWAHD KQSLAIAVVN PTALAMLKPP
260 270 280 290 300
GEWGRQGADI AVGEGQPLGI PLSSGGPYFG FMACKQELVR QMPGRIIGRT
310 320 330 340 350
TDLEGKEGFA LTLQAREQHI RRSKATSNIC TNQGLMVTAA TIYMSLLGPE
360 370 380 390 400
GLYRVAAQSH ANTLALVEQL ETLPGVKKAF HSPFFHEAVL QLSVPADEVL
410 420 430 440 450
NKLKAQGVLG GVLLENYYPD LKNTLLVCAT ETKIAEDLDK YTEMLRQILK

A
Length:451
Mass (Da):49,512
Last modified:October 17, 2006 - v1
Checksum:i1C182493E485E078
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000450 Genomic DNA Translation: ABI60183.1
RefSeqiWP_011634984.1, NC_008344.1

Genome annotation databases

EnsemblBacteriaiABI60183; ABI60183; Neut_1953
KEGGinet:Neut_1953

Similar proteinsi

Entry informationi

Entry nameiGCSPA_NITEC
AccessioniPrimary (citable) accession number: Q0AEP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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