Reviewed, UniProtKB/Swiss-Prot Q0AEP9 (GCSPA_NITEC)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Neut_1953

Organism

Nitrosomonas eutropha (strain C91) [Complete proteome] [HAMAP]

Taxonomic identifier

335283 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045670

Sequences

	Sequence		Length	Mass (Da)
	Q0AEP9-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 1C182493E485E078	FASTA	451	49,512
	10 20 30 40 50 60 MPFIPHTEED VTEMLASIGA TSIDELFDEI PAELKNGKLT QVPTGMSEME ISRLMYERAQ 70 80 90 100 110 120 KDGFYLSFIG AGAYEHHIPA AVWQITTRGE FYSSYTPYQA EASQGTLQLL YEYQTMMASL 130 140 150 160 170 180 AGMDVSNASL YDGASALAEA ALMAVRQHKS SRRILVPQTV HPIYRSVVRT IVRNQAIEVV 190 200 210 220 230 240 EVPYDPATGQ VSIDQLDQFA QEEFAALIIP QPNFFGVLEQ VDTLADWAHD KQSLAIAVVN 250 260 270 280 290 300 PTALAMLKPP GEWGRQGADI AVGEGQPLGI PLSSGGPYFG FMACKQELVR QMPGRIIGRT 310 320 330 340 350 360 TDLEGKEGFA LTLQAREQHI RRSKATSNIC TNQGLMVTAA TIYMSLLGPE GLYRVAAQSH 370 380 390 400 410 420 ANTLALVEQL ETLPGVKKAF HSPFFHEAVL QLSVPADEVL NKLKAQGVLG GVLLENYYPD 430 440 450 LKNTLLVCAT ETKIAEDLDK YTEMLRQILK A

References

[1]

"Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation." Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X. Environ. Microbiol. 9:2993-3007(2007) [PubMed: 17991028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000450 Genomic DNA. Translation: ABI60183.1.
RefSeq	YP_748148.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4273340.
GenomeReviews	Gene locus Neut_1953 in contig CP000450_GR.
KEGG	net:Neut_1953.
NMPDR	fig|335283.3.peg.1076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q0AEP9. VANASMY.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_NITEC

Accession

Primary (citable) accession number: Q0AEP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)