Reviewed, UniProtKB/Swiss-Prot Q0AEP6 (HEM6_NITEC)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase
    EC=1.3.3.3

Gene names

Name:	hemF
Ordered Locus Names:	Neut_1956

Organism

Nitrosomonas eutropha (strain C91) [Complete proteome] [HAMAP]

Taxonomic identifier

335283 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Coproporphyrinogen III oxidase, aerobic		PRO_1000019473

Sequences

	Sequence		Length	Mass (Da)
	Q0AEP6-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 6C297DF69EA1825D	FASTA	301	34,003
	10 20 30 40 50 60 MDFAQVKDYL VNLQNNIVAG LEQADGGSFR RDSWDRPEGG GGTSCVIEEG NVLERGGVNF 70 80 90 100 110 120 SHVHGKGLPA SATAARPELA GRAFEAAGVS LVLHPRNPYA PTVHMNVRFF AAIKEGAEPV 130 140 150 160 170 180 WWFGGGMDLT PYYGFEEDAI HFHQICKHAL QPSGSEYYPR FKKWCDEYFY LKHRKEPRGI 190 200 210 220 230 240 GGVFFDDLNQ PDFVTCFNLT KSVGDQFLAA YVPILQKRCN LPYGERERDF QAYRRGRYVE 250 260 270 280 290 300 FNLVWDRGTL FGLQSGGRTE SILMSLPPIV KWRYDWSPAA GSPEAKLYTD FLIGKDWLPL D

References

[1]

"Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation." Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X. Environ. Microbiol. 9:2993-3007(2007) [PubMed: 17991028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000450 Genomic DNA. Translation: ABI60186.1.
RefSeq	YP_748151.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4273308.
GenomeReviews	Gene locus Neut_1956 in contig CP000450_GR.
KEGG	net:Neut_1956.
NMPDR	fig|335283.3.peg.1081.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_NITEC

Accession

Primary (citable) accession number: Q0AEP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	November 4, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)