Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0AEG4

- Q0AEG4_NITEC

UniProt

Q0AEG4 - Q0AEG4_NITEC

Protein

Isocitrate dehydrogenase [NADP]

Gene

Neut_2045

Organism
Nitrosomonas eutropha (strain C91)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciNEUT335283:GHT6-2083-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Neut_2045Imported
    OrganismiNitrosomonas eutropha (strain C91)Imported
    Taxonomic identifieri335283 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
    ProteomesiUP000001966: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi335283.Neut_2045.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AEG4.
    SMRiQ0AEG4. Positions 1-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiRYAIDND.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0AEG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQHIKVPAI GSKIQVKNDS TLIVPDNPII PFIEGDGTGI DITPVMIKVI    50
    DGAVKKAYGD SRKISWMEIY AGEKSTRVYG QDVWLPDETL QAAKEFVVSI 100
    KGPLTTPVSG GIRSINVALR QLLDLYVCLR PVRYFQGVPS PVKQPEKVDM 150
    IIFRENSEDI YAGIEWEAGT AAVGKVINFL TTEMEITKIR FPQSSAIGIK 200
    PVSKEGSERL IRKAIQYAID HKRRSVTLVH KGNIMKFTEG AFKKWGYELA 250
    AKEFGAELLD GGPWMKLRYD GNEITIKDVI ADAFLQQILL RPDEYDVIAT 300
    LNLNGDYISD ALAAQVGGIG IAPGANLSDS IAIFEATHGT APKYAGKDQV 350
    NPGSIILSAE MMLRYINWHE AADIIISSME KTIQDKIMTY DLARLTPNAR 400
    QATSSEFGSA MIQRM 415
    Length:415
    Mass (Da):45,830
    Last modified:October 17, 2006 - v1
    Checksum:i00DB564D2B8AC109
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000450 Genomic DNA. Translation: ABI60268.1.
    RefSeqiYP_748233.1. NC_008344.1.

    Genome annotation databases

    EnsemblBacteriaiABI60268; ABI60268; Neut_2045.
    GeneIDi4273222.
    KEGGinet:Neut_2045.
    PATRICi22721690. VBINitEut7577_2491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000450 Genomic DNA. Translation: ABI60268.1 .
    RefSeqi YP_748233.1. NC_008344.1.

    3D structure databases

    ProteinModelPortali Q0AEG4.
    SMRi Q0AEG4. Positions 1-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 335283.Neut_2045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI60268 ; ABI60268 ; Neut_2045 .
    GeneIDi 4273222.
    KEGGi net:Neut_2045.
    PATRICi 22721690. VBINitEut7577_2491.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi RYAIDND.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci NEUT335283:GHT6-2083-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
      Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
      Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C91Imported.

    Entry informationi

    Entry nameiQ0AEG4_NITEC
    AccessioniPrimary (citable) accession number: Q0AEG4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3