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Q0AEG4

- Q0AEG4_NITEC

UniProt

Q0AEG4 - Q0AEG4_NITEC

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Neut_2045
Organism
Nitrosomonas eutropha (strain C91)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciNEUT335283:GHT6-2083-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Neut_2045Imported
OrganismiNitrosomonas eutropha (strain C91)Imported
Taxonomic identifieri335283 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001966: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi335283.Neut_2045.

Structurei

3D structure databases

ProteinModelPortaliQ0AEG4.
SMRiQ0AEG4. Positions 1-415.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRYAIDND.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AEG4-1 [UniParc]FASTAAdd to Basket

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MYQHIKVPAI GSKIQVKNDS TLIVPDNPII PFIEGDGTGI DITPVMIKVI    50
DGAVKKAYGD SRKISWMEIY AGEKSTRVYG QDVWLPDETL QAAKEFVVSI 100
KGPLTTPVSG GIRSINVALR QLLDLYVCLR PVRYFQGVPS PVKQPEKVDM 150
IIFRENSEDI YAGIEWEAGT AAVGKVINFL TTEMEITKIR FPQSSAIGIK 200
PVSKEGSERL IRKAIQYAID HKRRSVTLVH KGNIMKFTEG AFKKWGYELA 250
AKEFGAELLD GGPWMKLRYD GNEITIKDVI ADAFLQQILL RPDEYDVIAT 300
LNLNGDYISD ALAAQVGGIG IAPGANLSDS IAIFEATHGT APKYAGKDQV 350
NPGSIILSAE MMLRYINWHE AADIIISSME KTIQDKIMTY DLARLTPNAR 400
QATSSEFGSA MIQRM 415
Length:415
Mass (Da):45,830
Last modified:October 17, 2006 - v1
Checksum:i00DB564D2B8AC109
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI60268.1.
RefSeqiYP_748233.1. NC_008344.1.

Genome annotation databases

EnsemblBacteriaiABI60268; ABI60268; Neut_2045.
GeneIDi4273222.
KEGGinet:Neut_2045.
PATRICi22721690. VBINitEut7577_2491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000450 Genomic DNA. Translation: ABI60268.1 .
RefSeqi YP_748233.1. NC_008344.1.

3D structure databases

ProteinModelPortali Q0AEG4.
SMRi Q0AEG4. Positions 1-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 335283.Neut_2045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI60268 ; ABI60268 ; Neut_2045 .
GeneIDi 4273222.
KEGGi net:Neut_2045.
PATRICi 22721690. VBINitEut7577_2491.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi RYAIDND.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci NEUT335283:GHT6-2083-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
    Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
    Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C91Imported.

Entry informationi

Entry nameiQ0AEG4_NITEC
AccessioniPrimary (citable) accession number: Q0AEG4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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