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Q0AEG4 (Q0AEG4_NITEC) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Ordered Locus Names:Neut_2045 EMBL ABI60268.1
OrganismNitrosomonas eutropha (strain C91) [Complete proteome] [HAMAP] EMBL ABI60268.1
Taxonomic identifier335283 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
Q0AEG4 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 00DB564D2B8AC109

FASTA41545,830
        10         20         30         40         50         60 
MYQHIKVPAI GSKIQVKNDS TLIVPDNPII PFIEGDGTGI DITPVMIKVI DGAVKKAYGD 

        70         80         90        100        110        120 
SRKISWMEIY AGEKSTRVYG QDVWLPDETL QAAKEFVVSI KGPLTTPVSG GIRSINVALR 

       130        140        150        160        170        180 
QLLDLYVCLR PVRYFQGVPS PVKQPEKVDM IIFRENSEDI YAGIEWEAGT AAVGKVINFL 

       190        200        210        220        230        240 
TTEMEITKIR FPQSSAIGIK PVSKEGSERL IRKAIQYAID HKRRSVTLVH KGNIMKFTEG 

       250        260        270        280        290        300 
AFKKWGYELA AKEFGAELLD GGPWMKLRYD GNEITIKDVI ADAFLQQILL RPDEYDVIAT 

       310        320        330        340        350        360 
LNLNGDYISD ALAAQVGGIG IAPGANLSDS IAIFEATHGT APKYAGKDQV NPGSIILSAE 

       370        380        390        400        410 
MMLRYINWHE AADIIISSME KTIQDKIMTY DLARLTPNAR QATSSEFGSA MIQRM 

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References

[1]"Whole-genome analysis of the ammonia-oxidizing bacterium, Nitrosomonas eutropha C91: implications for niche adaptation."
Stein L.Y., Arp D.J., Berube P.M., Chain P.S., Hauser L., Jetten M.S., Klotz M.G., Larimer F.W., Norton J.M., Op den Camp H.J.M., Shin M., Wei X.
Environ. Microbiol. 9:2993-3007(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C91 EMBL ABI60268.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000450 Genomic DNA. Translation: ABI60268.1.
RefSeqYP_748233.1. NC_008344.1.

3D structure databases

ProteinModelPortalQ0AEG4.
SMRQ0AEG4. Positions 1-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING335283.Neut_2045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI60268; ABI60268; Neut_2045.
GeneID4273222.
KEGGnet:Neut_2045.
PATRIC22721690. VBINitEut7577_2491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000021113.
KOK00031.
OMARYAIDND.
OrthoDBEOG6SNDTP.

Enzyme and pathway databases

BioCycNEUT335283:GHT6-2083-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0AEG4_NITEC
AccessionPrimary (citable) accession number: Q0AEG4
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)