Reviewed, UniProtKB/Swiss-Prot Q0ACL9 (DAPF_ALHEH)

Names and origin

Protein names

Recommended name:
    Diaminopimelate epimerase
      Short name=DAP epimerase
    EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	Mlg_0061

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-diaminopimelate from LL-diaminopimelate: step 1/1. HAMAP MF_00197
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Diaminopimelate epimerase HAMAP MF_00197		PRO_1000011832
Sites
	Active site	75	1	By similarity
	Active site	221	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0ACL9-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 864915CA9A0E9EFF	FASTA	279	30,481
	10 20 30 40 50 60 MKVRFTKMQG LGNDFVVIDA VRQPVEPSPE QIRHIADRRY GVGCDQVLLA TPARRSQADF 70 80 90 100 110 120 GYLIFNPDGS QAEHCGNGVR CLARFLDDRG LVPAGRHELV IETINGLSRV RLCDDGPVTV 130 140 150 160 170 180 DMGAPVLEPP HIPFRAPSRA REYELEVEGQ VVRLGAVSMG NPHAVLRVDD VDSAPVETLG 190 200 210 220 230 240 PAIESHSRFP RRVNVGFMQV LTPTHIRLRV YERGAGETLA CGTGACAAVV SGRLRGWLEE 250 260 270 AVDVDLPGGR LVIHWAGDGE HVWMTGPAET VFEGEIRLD

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI55418.1.
RefSeq	YP_740908.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4270339.
GenomeReviews	Gene locus Mlg_0061 in contig CP000453_GR.
KEGG	aeh:Mlg_0061.
NMPDR	fig|187272.6.peg.57.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0ACL9.
OMA	Q0ACL9. PHAVLRV.
Family and domain databases
HAMAP	MF_00197. [Tree]
InterPro	IPR001653. DAP_epimerase. IPR018510. DAP_epimerase_CS. [Graphical view]
Pfam	PF01678. DAP_epimerase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00652. DapF. 1 hit.
PROSITE	PS01326. DAP_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPF_ALHEH

Accession

Primary (citable) accession number: Q0ACL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)