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Q0ACK8

- SPEA_ALKEH

UniProt

Q0ACK8 - SPEA_ALKEH

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-72-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:Mlg_0072
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Biosynthetic arginine decarboxylasePRO_1000024253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi187272.Mlg_0072.

Structurei

3D structure databases

ProteinModelPortaliQ0ACK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 29111Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ACK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDWSIGLAR QVWSVQHWSG GYFDISDEGR VVARPDRDPA RAPLDLAGIA
60 70 80 90 100
AEARHQGLGL PVLVRFLDIL HDRVDSLCQA FRQAMVEDGY RGGYRAVYPI
110 120 130 140 150
KVNQQRRVVE EIIRHGNGRV GLEAGSKPEL MAVLALTPPG GTVVCNGYKD
160 170 180 190 200
REYVRLALRG RQLGLQVHLV IEKASELELV LEEAAALGVT PSLGMRVRLA
210 220 230 240 250
TIGAGKWQNT GGEKSKFGLT AAQALAVVDR LRAAGCLDWL RLLHFHLGSQ
260 270 280 290 300
IPNIRDIRRG MREAARYYAE LRALGAPVET VDVGGGLGVD YEGSRSRSFC
310 320 330 340 350
SMNYTVAEYA HNVVHALWQV CEDEGLPHPD IITESGRAMT AHHAVLITDV
360 370 380 390 400
IDGDRVPGGA DLLAPADAAP RVLHELWTVW TGLDRRHPLE AYHDAAHGLA
410 420 430 440 450
EAQELYAHGV LNLTDRARAE RIWQAVCHAL LQRLDPRRRP HRELLDELNE
460 470 480 490 500
KLADKLFCNF SLFQSMPDVW AIDQIFPVLP LQRLDEPPAS RAVLQDLTCD
510 520 530 540 550
SDGCIRGYVD RDGVESTLPL PPWRPGEPYL LGIFLVGAYQ EILGDMHNLF
560 570 580 590 600
GDTHSVNVRL TGEGYALSGA AHGDTITDVL RYVDFDAEVL RGIYRERVVA
610 620
AAGLDATARA QCLADLEAGL RGYTYLDT
Length:628
Mass (Da):69,264
Last modified:October 17, 2006 - v1
Checksum:i984DD1693C8BB682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA. Translation: ABI55429.1.
RefSeqiYP_740919.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI55429; ABI55429; Mlg_0072.
GeneIDi4270350.
KEGGiaeh:Mlg_0072.
PATRICi20859316. VBIAlkEhr114327_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA. Translation: ABI55429.1 .
RefSeqi YP_740919.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0ACK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_0072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI55429 ; ABI55429 ; Mlg_0072 .
GeneIDi 4270350.
KEGGi aeh:Mlg_0072.
PATRICi 20859316. VBIAlkEhr114327_0073.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci AEHR187272:GHAX-72-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiSPEA_ALKEH
AccessioniPrimary (citable) accession number: Q0ACK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3