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Q0ACK8 (SPEA_ALKEH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Mlg_0072
OrganismAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000024253

Regions

Region281 – 29111Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0ACK8 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 984DD1693C8BB682

FASTA62869,264
        10         20         30         40         50         60 
MSDWSIGLAR QVWSVQHWSG GYFDISDEGR VVARPDRDPA RAPLDLAGIA AEARHQGLGL 

        70         80         90        100        110        120 
PVLVRFLDIL HDRVDSLCQA FRQAMVEDGY RGGYRAVYPI KVNQQRRVVE EIIRHGNGRV 

       130        140        150        160        170        180 
GLEAGSKPEL MAVLALTPPG GTVVCNGYKD REYVRLALRG RQLGLQVHLV IEKASELELV 

       190        200        210        220        230        240 
LEEAAALGVT PSLGMRVRLA TIGAGKWQNT GGEKSKFGLT AAQALAVVDR LRAAGCLDWL 

       250        260        270        280        290        300 
RLLHFHLGSQ IPNIRDIRRG MREAARYYAE LRALGAPVET VDVGGGLGVD YEGSRSRSFC 

       310        320        330        340        350        360 
SMNYTVAEYA HNVVHALWQV CEDEGLPHPD IITESGRAMT AHHAVLITDV IDGDRVPGGA 

       370        380        390        400        410        420 
DLLAPADAAP RVLHELWTVW TGLDRRHPLE AYHDAAHGLA EAQELYAHGV LNLTDRARAE 

       430        440        450        460        470        480 
RIWQAVCHAL LQRLDPRRRP HRELLDELNE KLADKLFCNF SLFQSMPDVW AIDQIFPVLP 

       490        500        510        520        530        540 
LQRLDEPPAS RAVLQDLTCD SDGCIRGYVD RDGVESTLPL PPWRPGEPYL LGIFLVGAYQ 

       550        560        570        580        590        600 
EILGDMHNLF GDTHSVNVRL TGEGYALSGA AHGDTITDVL RYVDFDAEVL RGIYRERVVA 

       610        620 
AAGLDATARA QCLADLEAGL RGYTYLDT 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000453 Genomic DNA. Translation: ABI55429.1.
RefSeqYP_740919.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0ACK8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING187272.Mlg_0072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI55429; ABI55429; Mlg_0072.
GeneID4270350.
KEGGaeh:Mlg_0072.
PATRIC20859316. VBIAlkEhr114327_0073.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycAEHR187272:GHAX-72-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_ALKEH
AccessionPrimary (citable) accession number: Q0ACK8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways