Q0ACJ6 (ARGB_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Mlg_0084

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000264679
Regions
	Region	74 – 75	2	Substrate binding By similarity
Sites
	Binding site	96	1	Substrate By similarity
	Binding site	201	1	Substrate By similarity
	Site	39	1	Transition state stabilizer By similarity
	Site	261	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0ACJ6 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 2F2400D5A61AAE77	FASTA	304	32,232
	10 20 30 40 50 60 MTDTTINNAD KVAPTLVARV LNEALPYIRR FSGKTIVVKF GGNAMVDDAL KQSFARDIVL 70 80 90 100 110 120 MKLVGFNPVV VHGGGPQIGK LLERIGKHTE FVQGMRVTDA ETMDVVEMVL GGLVNKEIVN 130 140 150 160 170 180 LINSQGGRAV GLTGKDGGMI RARRLRLSHQ DAAEQPPEII DIGHVGEVEH IDPSVVDMLD 190 200 210 220 230 240 HGAFIPVIAP IGVGEDGLSY NINADLVAGK IAEVLEAEKL MLLTNTPGVL SKQGELLTGL 250 260 270 280 290 300 NPARVDALIQ DGTIAGGMLP KIRCALDAVA GGVNAAHIID GRVEHACLLE LFTDAGVGTL IQRR

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MLHE-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000453 Genomic DNA. Translation: ABI55441.1.
RefSeq	YP_740931.1. NC_008340.1.
3D structure databases
ProteinModelPortal	Q0ACJ6.
SMR	Q0ACJ6. Positions 17-304.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0ACJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4269912.
GenomeReviews	Gene locus Mlg_0084 in contig CP000453_GR.
KEGG	aeh:Mlg_0084.
NMPDR	fig|187272.6.peg.80.
PATRIC	20859340. VBIAlkEhr114327_0085.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGNAMID.
PhylomeDB	Q0ACJ6.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	AEHR187272:MLG_0084-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ALHEH

Accession

Primary (citable) accession number: Q0ACJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program