ID   Q0ACB9_ALKEH            Unreviewed;       331 AA.
AC   Q0ACB9;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569, ECO:0000256|RuleBase:RU366046};
DE            EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN   OrderedLocusNames=Mlg_0163 {ECO:0000313|EMBL:ABI55518.1};
OS   Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272 {ECO:0000313|EMBL:ABI55518.1, ECO:0000313|Proteomes:UP000001962};
RN   [1] {ECO:0000313|Proteomes:UP000001962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1
RC   {ECO:0000313|Proteomes:UP000001962};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S.,
RA   Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B.,
RA   Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC         Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC         EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC         ECO:0000256|RuleBase:RU366046};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911,
CC         ECO:0000256|RuleBase:RU366046};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
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DR   EMBL; CP000453; ABI55518.1; -; Genomic_DNA.
DR   RefSeq; WP_011627914.1; NC_008340.1.
DR   AlphaFoldDB; Q0ACB9; -.
DR   KEGG; aeh:Mlg_0163; -.
DR   eggNOG; COG1087; Bacteria.
DR   HOGENOM; CLU_007383_1_10_6; -.
DR   OrthoDB; 9803010at2; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000001962; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005886; UDP_G4E.
DR   NCBIfam; TIGR01179; galE; 1.
DR   PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR   PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW   Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW   Isomerase {ECO:0000256|RuleBase:RU366046, ECO:0000313|EMBL:ABI55518.1};
KW   NAD {ECO:0000256|RuleBase:RU366046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001962}.
FT   DOMAIN          3..251
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   331 AA;  35797 MW;  D771181D61FDC753 CRC64;
     MRVLVTGGAG YIGSHVVRQL LAAGHEPVVY DNLSTGFAWA VGEAPLVRAD LADTAQLAET
     LARHAFDAVL HFAAHTVVPE SLSDPLRYYG NNTRNTWQLL QACHEAGVKR FVFSSTAAVY
     GMPETMPVAE DAPLAPINPY GASKMMSERM LMDLGAASDL RYVCLRYFNV AGAEPSGRLG
     QATPQATHLI KVACEAAVGR RDGVTVFGTD YATPDGTCVR DFIHVEDLAR AHIQALSHLV
     DGGDSQVLNC GYGRGYSVLE VLEAVKRLSG ADFPVTLGTR RAGDPAQVVA DNRRILRTLD
     WSPRYADLDT IVAHALAWER DGLLARRGPR R
//