ID   APAH_ALHEH              Reviewed;         279 AA.
AC   Q0AC59;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=Mlg_0223;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; CP000453; ABI55578.1; -; Genomic_DNA.
DR   RefSeq; YP_741068.1; -.
DR   GeneID; 4268923; -.
DR   GenomeReviews; CP000453_GR; Mlg_0223.
DR   KEGG; aeh:Mlg_0223; -.
DR   NMPDR; fig|187272.6.peg.211; -.
DR   HOGENOM; Q0AC59; -.
DR   OMA; Q0AC59; LVFGHWA.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    279       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000012043.
SQ   SEQUENCE   279 AA;  31706 MW;  D47917B0BE68AD51 CRC64;
     MAVYAIGDLQ GCLSPLEALL EQLRFDPARD RIWFVGDLVN RGPDSVRVLR YVRALGEAAV
     TTLGNHDLHL LAVWAGTARA KRKDTVHQVL DAPDGEELLH WLRFQHLTWR DDDLGYFMVH
     AGVPPVWSLD EAETRGRELE AVLRSEDYLA FFENMYGNQP DRWDEGLTGW DRLRYICNAF
     TRMRYVDADG RLDLRCNSAP GSQPDGLYPW YEVRERLRPE PDPLTIVSGH WSTLGLCQRG
     GNVAIDTGCL WGGSLTALRL DSDEREIISR PCPAFLEPK
//