Reviewed, UniProtKB/Swiss-Prot Q0AC59 (APAH_ALHEH)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	Mlg_0223

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000012043

Sequences

	Sequence		Length	Mass (Da)
	Q0AC59-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: D47917B0BE68AD51	FASTA	279	31,706
	10 20 30 40 50 60 MAVYAIGDLQ GCLSPLEALL EQLRFDPARD RIWFVGDLVN RGPDSVRVLR YVRALGEAAV 70 80 90 100 110 120 TTLGNHDLHL LAVWAGTARA KRKDTVHQVL DAPDGEELLH WLRFQHLTWR DDDLGYFMVH 130 140 150 160 170 180 AGVPPVWSLD EAETRGRELE AVLRSEDYLA FFENMYGNQP DRWDEGLTGW DRLRYICNAF 190 200 210 220 230 240 TRMRYVDADG RLDLRCNSAP GSQPDGLYPW YEVRERLRPE PDPLTIVSGH WSTLGLCQRG 250 260 270 GNVAIDTGCL WGGSLTALRL DSDEREIISR PCPAFLEPK

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI55578.1.
RefSeq	YP_741068.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4268923.
GenomeReviews	Gene locus Mlg_0223 in contig CP000453_GR.
KEGG	aeh:Mlg_0223.
NMPDR	fig|187272.6.peg.211.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0AC59.
OMA	Q0AC59. LVFGHWA.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_ALHEH

Accession

Primary (citable) accession number: Q0AC59

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)