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Q0AC59 (APAH_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene names
Name:apaH
Ordered Locus Names:Mlg_0223
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP MF_00199

Catalytic activity

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199

Sequence similarities

Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199
PRO_1000012043

Sequences

Sequence LengthMass (Da)Tools
Q0AC59 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: D47917B0BE68AD51

FASTA27931,706
        10         20         30         40         50         60 
MAVYAIGDLQ GCLSPLEALL EQLRFDPARD RIWFVGDLVN RGPDSVRVLR YVRALGEAAV 

        70         80         90        100        110        120 
TTLGNHDLHL LAVWAGTARA KRKDTVHQVL DAPDGEELLH WLRFQHLTWR DDDLGYFMVH 

       130        140        150        160        170        180 
AGVPPVWSLD EAETRGRELE AVLRSEDYLA FFENMYGNQP DRWDEGLTGW DRLRYICNAF 

       190        200        210        220        230        240 
TRMRYVDADG RLDLRCNSAP GSQPDGLYPW YEVRERLRPE PDPLTIVSGH WSTLGLCQRG 

       250        260        270 
GNVAIDTGCL WGGSLTALRL DSDEREIISR PCPAFLEPK

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI55578.1.
RefSeqYP_741068.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0AC59.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0AC59.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4268923.
GenomeReviewsGene locus Mlg_0223 in contig CP000453_GR.
KEGGaeh:Mlg_0223.
NMPDRfig|187272.6.peg.211.
PATRIC20859606. VBIAlkEhr114327_0217.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHBG724457.
OMALVFGHWA.
PhylomeDBQ0AC59.
ProtClustDBPRK00166.

Enzyme and pathway databases

BioCycAEHR187272:MLG_0223-MONOMER.

Family and domain databases

HAMAPMF_00199. ApaH.
[Tree]
InterProIPR004617. ApaH.
IPR004843. Metallo_PEstase_dom.
[Graphical view]
KOK01525.
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMsTIGR00668. ApaH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAPAH_ALHEH
AccessionPrimary (citable) accession number: Q0AC59
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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