ID   PYRB_ALHEH              Reviewed;         321 AA.
AC   Q0ABT6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=Mlg_0346;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000453; ABI55701.1; -; Genomic_DNA.
DR   RefSeq; YP_741191.1; -.
DR   GeneID; 4268334; -.
DR   GenomeReviews; CP000453_GR; Mlg_0346.
DR   KEGG; aeh:Mlg_0346; -.
DR   NMPDR; fig|187272.6.peg.330; -.
DR   HOGENOM; Q0ABT6; -.
DR   OMA; Q0ABT6; CHANIIN.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    321       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000321066.
SQ   SEQUENCE   321 AA;  35130 MW;  52C8EF6F18D918F1 CRC64;
     MNAQLDNQGR LRHFLTTEGL PRPLLNQILD TAESFTGVIG KSVKKVPLLR GRTVINLFFE
     PSTRTRTTFE LAATRLSADV LNIDVAVSSQ SKGESLLDML RNLEAMQCDA FVVRHGDSGT
     AEFIARHVRP GVSVLNAGDG RHAHPTQAML DMFTIRQHKG DFEPLRVAIV GDILHSRVAR
     SQIHALNGLG AGEVRVIAPR TLLPRDVETL GVRVFHDMQA GLRDVDVVMM LRLQRERMRG
     ALLPSEGEYF KLYGLTEEKL SVAHPDAIIM HPGPINRGVE MNSAVADGPR SVILQQVTNG
     IAVRMALMSM LLGRAGGGED A
//