Reviewed, UniProtKB/Swiss-Prot Q0ABT6 (PYRB_ALHEH)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Mlg_0346

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Aspartate carbamoyltransferase		PRO_0000321066

Sequences

	Sequence		Length	Mass (Da)
	Q0ABT6-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 52C8EF6F18D918F1	FASTA	321	35,130
	10 20 30 40 50 60 MNAQLDNQGR LRHFLTTEGL PRPLLNQILD TAESFTGVIG KSVKKVPLLR GRTVINLFFE 70 80 90 100 110 120 PSTRTRTTFE LAATRLSADV LNIDVAVSSQ SKGESLLDML RNLEAMQCDA FVVRHGDSGT 130 140 150 160 170 180 AEFIARHVRP GVSVLNAGDG RHAHPTQAML DMFTIRQHKG DFEPLRVAIV GDILHSRVAR 190 200 210 220 230 240 SQIHALNGLG AGEVRVIAPR TLLPRDVETL GVRVFHDMQA GLRDVDVVMM LRLQRERMRG 250 260 270 280 290 300 ALLPSEGEYF KLYGLTEEKL SVAHPDAIIM HPGPINRGVE MNSAVADGPR SVILQQVTNG 310 320 IAVRMALMSM LLGRAGGGED A

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI55701.1.
RefSeq	YP_741191.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4268334.
GenomeReviews	Gene locus Mlg_0346 in contig CP000453_GR.
KEGG	aeh:Mlg_0346.
NMPDR	fig|187272.6.peg.330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0ABT6.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ALHEH

Accession

Primary (citable) accession number: Q0ABT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 17, 2006
Last modified:	November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)