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Q0ABN3

- SYL_ALKEH

UniProt

Q0ABN3 - SYL_ALKEH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei624 – 6241ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAEHR187272:GHAX-407-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mlg_0400
    OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
    Taxonomic identifieri187272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
    ProteomesiUP000001962: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 864864Leucine--tRNA ligasePRO_1000009288Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187272.Mlg_0400.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0ABN3.
    SMRiQ0ABN3. Positions 228-413.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi621 – 6255"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0ABN3-1 [UniParc]FASTAAdd to Basket

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    MDASYQPEQI EAQAQRYWDE QQSFAAREER EGEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMQG RNVLQPMGWD AFGLPAENAA MKHGVPPARW 100
    TRENIETMRG QLQRLGFAYD WDREFATCDP EYYRWEQWLF TRLYKKGLVY 150
    KKTATVNWDP VDQTVLANEQ VVDGRGWRSG AVVERRDIPQ WFLRITDYAD 200
    ELLEALDELP GWPEQVRAMQ RNWIGRSEGV ELDFAVAGHS DTLRVYTTRP 250
    DTLYGVTYVG LAPEHPLAAE AAEGNPEMQR FIEDCRKGGV AEADIATMEK 300
    RGMDTGLKAV HPLTGEQVPI WVANFVLMEY GHGAVMAVPA HDQRDWEFAS 350
    KYGLDIRPVV HPSAEERADV SEGAFTDDGV LADSGEFSGL PSAEARQAIG 400
    EKLEGLGKGE RTVNYRLRDW GISRQRYWGA PIPMIQCPAC GDVPVPDEDL 450
    PVVLPEDVDV TGGGSPLKDL PAFYQTTCPQ CGGEARRETD TFDTFMESSW 500
    YYARFACADQ KGAMLDERAD QWLPVDQYIG GIEHAILHLL YARFFHKLMR 550
    DEGLLQSDEP FRNLLTQGMV IAETYYRERG DGGKDWYNPA EVTVQRDERG 600
    RPVSAVLEDD GEPVVMGAIE KMSKSKNNGV DPQALIDRYG ADTVRLYTMF 650
    AAPPDQSLEW SDSAVEGAYR FLRRYYGLVR DHVAAGPVPA LDVASLDDAA 700
    RDLRRKVHET IAKASDDVGR RYTFNTAIAA VMELCNALGK AAANEPSGAA 750
    RAVLQEGLEA ATLILAPIAP HVTHVCWQAL GHDEAVIDAR WPAVDESALT 800
    RDTIELVVQV NGKLRSRLQL PADADKAAAE AAALADEKVQ RFTEGKTVRK 850
    VIVVPGKLVN IVAN 864
    Length:864
    Mass (Da):96,603
    Last modified:October 17, 2006 - v1
    Checksum:i49BADF5A7AD2469E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI55754.1.
    RefSeqiYP_741244.1. NC_008340.1.

    Genome annotation databases

    EnsemblBacteriaiABI55754; ABI55754; Mlg_0400.
    GeneIDi4269978.
    KEGGiaeh:Mlg_0400.
    PATRICi20859966. VBIAlkEhr114327_0390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI55754.1 .
    RefSeqi YP_741244.1. NC_008340.1.

    3D structure databases

    ProteinModelPortali Q0ABN3.
    SMRi Q0ABN3. Positions 228-413.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187272.Mlg_0400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI55754 ; ABI55754 ; Mlg_0400 .
    GeneIDi 4269978.
    KEGGi aeh:Mlg_0400.
    PATRICi 20859966. VBIAlkEhr114327_0390.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AEHR187272:GHAX-407-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

    Entry informationi

    Entry nameiSYL_ALKEH
    AccessioniPrimary (citable) accession number: Q0ABN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3