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Q0ABN3

- SYL_ALKEH

UniProt

Q0ABN3 - SYL_ALKEH

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Protein

Leucine--tRNA ligase

Gene
leuS, Mlg_0400
Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei624 – 6241ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-407-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mlg_0400
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligaseUniRule annotationPRO_1000009288Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187272.Mlg_0400.

Structurei

3D structure databases

ProteinModelPortaliQ0ABN3.
SMRiQ0ABN3. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi621 – 6255"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0ABN3-1 [UniParc]FASTAAdd to Basket

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MDASYQPEQI EAQAQRYWDE QQSFAAREER EGEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VISRYQRMQG RNVLQPMGWD AFGLPAENAA MKHGVPPARW 100
TRENIETMRG QLQRLGFAYD WDREFATCDP EYYRWEQWLF TRLYKKGLVY 150
KKTATVNWDP VDQTVLANEQ VVDGRGWRSG AVVERRDIPQ WFLRITDYAD 200
ELLEALDELP GWPEQVRAMQ RNWIGRSEGV ELDFAVAGHS DTLRVYTTRP 250
DTLYGVTYVG LAPEHPLAAE AAEGNPEMQR FIEDCRKGGV AEADIATMEK 300
RGMDTGLKAV HPLTGEQVPI WVANFVLMEY GHGAVMAVPA HDQRDWEFAS 350
KYGLDIRPVV HPSAEERADV SEGAFTDDGV LADSGEFSGL PSAEARQAIG 400
EKLEGLGKGE RTVNYRLRDW GISRQRYWGA PIPMIQCPAC GDVPVPDEDL 450
PVVLPEDVDV TGGGSPLKDL PAFYQTTCPQ CGGEARRETD TFDTFMESSW 500
YYARFACADQ KGAMLDERAD QWLPVDQYIG GIEHAILHLL YARFFHKLMR 550
DEGLLQSDEP FRNLLTQGMV IAETYYRERG DGGKDWYNPA EVTVQRDERG 600
RPVSAVLEDD GEPVVMGAIE KMSKSKNNGV DPQALIDRYG ADTVRLYTMF 650
AAPPDQSLEW SDSAVEGAYR FLRRYYGLVR DHVAAGPVPA LDVASLDDAA 700
RDLRRKVHET IAKASDDVGR RYTFNTAIAA VMELCNALGK AAANEPSGAA 750
RAVLQEGLEA ATLILAPIAP HVTHVCWQAL GHDEAVIDAR WPAVDESALT 800
RDTIELVVQV NGKLRSRLQL PADADKAAAE AAALADEKVQ RFTEGKTVRK 850
VIVVPGKLVN IVAN 864
Length:864
Mass (Da):96,603
Last modified:October 17, 2006 - v1
Checksum:i49BADF5A7AD2469E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI55754.1.
RefSeqiYP_741244.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI55754; ABI55754; Mlg_0400.
GeneIDi4269978.
KEGGiaeh:Mlg_0400.
PATRICi20859966. VBIAlkEhr114327_0390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI55754.1 .
RefSeqi YP_741244.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0ABN3.
SMRi Q0ABN3. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_0400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI55754 ; ABI55754 ; Mlg_0400 .
GeneIDi 4269978.
KEGGi aeh:Mlg_0400.
PATRICi 20859966. VBIAlkEhr114327_0390.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AEHR187272:GHAX-407-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiSYL_ALKEH
AccessioniPrimary (citable) accession number: Q0ABN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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