Reviewed, UniProtKB/Swiss-Prot Q0ABJ9 (ARGC_ALHEH)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Mlg_0434

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010973
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0ABJ9-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 37E8B83615D5E0F0	FASTA	343	36,618
	10 20 30 40 50 60 MIEVGIVGGT GYTGVELLRL LARHPEARLR VITSRGNAGT RVDELFPSLR GEVELAFSEP 70 80 90 100 110 120 DVDRLAACDL VFFATPNGTA MQMVPDLLAR DTRVVDLGAD FRLKDVETWS RWYGMTHACP 130 140 150 160 170 180 ELVAEAAYGL PELNREAIRG ARLVANPGCY PTAVGLGWLP LLEAGLVETR GLVASCVSGA 190 200 210 220 230 240 SGAGRAANVA TLLCEVNESF KAYGADGHRH LPEIRQSLAQ VAGGAVELTF VPHLVPMTRG 250 260 270 280 290 300 MHASLYATLR GDAGDLQVLF EQRYADEPFV DVLPAGAHPE TRTVRGTNLC RLAVRRAPES 310 320 330 340 DQVIVLSVID NLTKGAAGQA VQNMNLMFGL PETAGLDAPA VLP

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI55788.1.
RefSeq	YP_741278.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4268287.
GenomeReviews	Gene locus Mlg_0434 in contig CP000453_GR.
KEGG	aeh:Mlg_0434.
NMPDR	fig|187272.6.peg.412.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0ABJ9.
OMA	Q0ABJ9. TAEDCTT.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ALHEH

Accession

Primary (citable) accession number: Q0ABJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)