Reviewed, UniProtKB/Swiss-Prot Q0ABB7 (PUR5_ALHEH)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	Mlg_0516

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_1000062155

Sequences

	Sequence		Length	Mass (Da)
	Q0ABB7-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: DE6866C06524B99A	FASTA	347	36,586
	10 20 30 40 50 60 MGPDQEGLTY KAAGVDIDAG NELVDRIRDD VKRTMRPGVL GGLGGFGGLF EVPVDRYRRP 70 80 90 100 110 120 VLVSGTDGVG TKLKLAIETG RHDGIGIDLV AMCANDVLVT GAEPLYFLDY YATGRLDVEV 130 140 150 160 170 180 AAAVIRGIAE GCHQAGAALI GGETAEMPGM YAEGHYDLAG FCVGVVEKDE IIDGSRVGAG 190 200 210 220 230 240 DALIALAASG PHSNGYSLIR KVLERAPEGA ATEVDGQPVA DLLMAPTRIY AKPVLDLIRN 250 260 270 280 290 300 LPVHAMAHIT GGGLPENLPR VLPEGLGAKL QPWSWPPVFR WLQQTGQIAE AEMLRTFNCG 310 320 330 340 VGMVLVVPAE QADAALQRLR QTGETAWRLG EIGTHEAGAP RVQVVAA

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI55870.1.
RefSeq	YP_741360.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4268868.
GenomeReviews	Gene locus Mlg_0516 in contig CP000453_GR.
KEGG	aeh:Mlg_0516.
NMPDR	fig|187272.6.peg.490.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0ABB7.
OMA	Q0ABB7. CGKLDPE.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ALHEH

Accession

Primary (citable) accession number: Q0ABB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)