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Q0ABB7

- PUR5_ALKEH

UniProt

Q0ABB7 - PUR5_ALKEH

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-534-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Mlg_0516
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000062155Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187272.Mlg_0516.

Structurei

3D structure databases

ProteinModelPortaliQ0ABB7.
SMRiQ0ABB7. Positions 8-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0ABB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPDQEGLTY KAAGVDIDAG NELVDRIRDD VKRTMRPGVL GGLGGFGGLF
60 70 80 90 100
EVPVDRYRRP VLVSGTDGVG TKLKLAIETG RHDGIGIDLV AMCANDVLVT
110 120 130 140 150
GAEPLYFLDY YATGRLDVEV AAAVIRGIAE GCHQAGAALI GGETAEMPGM
160 170 180 190 200
YAEGHYDLAG FCVGVVEKDE IIDGSRVGAG DALIALAASG PHSNGYSLIR
210 220 230 240 250
KVLERAPEGA ATEVDGQPVA DLLMAPTRIY AKPVLDLIRN LPVHAMAHIT
260 270 280 290 300
GGGLPENLPR VLPEGLGAKL QPWSWPPVFR WLQQTGQIAE AEMLRTFNCG
310 320 330 340
VGMVLVVPAE QADAALQRLR QTGETAWRLG EIGTHEAGAP RVQVVAA
Length:347
Mass (Da):36,586
Last modified:October 17, 2006 - v1
Checksum:iDE6866C06524B99A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI55870.1.
RefSeqiYP_741360.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI55870; ABI55870; Mlg_0516.
GeneIDi4268868.
KEGGiaeh:Mlg_0516.
PATRICi20860218. VBIAlkEhr114327_0505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI55870.1 .
RefSeqi YP_741360.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0ABB7.
SMRi Q0ABB7. Positions 8-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_0516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI55870 ; ABI55870 ; Mlg_0516 .
GeneIDi 4268868.
KEGGi aeh:Mlg_0516.
PATRICi 20860218. VBIAlkEhr114327_0505.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci AEHR187272:GHAX-534-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiPUR5_ALKEH
AccessioniPrimary (citable) accession number: Q0ABB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3