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Q0AB89 (ILVC_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:Mlg_0544
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000050476

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
Q0AB89 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 53B2C7AF5EC008DA

FASTA33836,223
        10         20         30         40         50         60 
MQVYYDKDAD LSIIQGKKVA VIGYGSQGHA HANNLKESGV DVVVGLREGS SSAAKAQKAG 

        70         80         90        100        110        120 
LAVASIEDAA AQADVVMILA PDEHQAVIYH NQIAPNVKPG AAIAFAHGFN IHFGQIQPAA 

       130        140        150        160        170        180 
DLDVIMVAPK GPGHLVRSTY VEGGGVPSLI AIHQDATGKA KDIALSYASA NGGGRAGVIE 

       190        200        210        220        230        240 
TSFREETETD LFGEQAVLCG GITSLIQAGF ETLVEAGYAP EMAYFECLHE TKLIVDLLYQ 

       250        260        270        280        290        300 
GGIANMRYSI SNTAEYGDFT RGPRVINEES REAMREILAE IQEGEFAREF VLENQAGCPT 

       310        320        330 
LTARRRLAAE HEIEVVGERL RGMMPWINAN KLVDKDKN

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI55898.1.
RefSeqYP_741388.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0AB89.
SMRQ0AB89. Positions 1-327.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0AB89.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4270299.
GenomeReviewsGene locus Mlg_0544 in contig CP000453_GR.
KEGGaeh:Mlg_0544.
NMPDRfig|187272.6.peg.517.
PATRIC20860274. VBIAlkEhr114327_0533.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG286525.
OMAMAYAKGI.
PhylomeDBQ0AB89.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycAEHR187272:MLG_0544-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_ALHEH
AccessionPrimary (citable) accession number: Q0AB89
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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