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Q0AAG2 (UPPP_ALKEH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Mlg_0821
OrganismAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290680

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane266 – 28621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0AAG2 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 9A92515DF581D1ED

FASTA29031,495
        10         20         30         40         50         60 
MALWIAALLG VIQGIFMFLP VSSTAHMVLT EHWLIARGET LPPPESAEMI LFALVVHVGT 

        70         80         90        100        110        120 
LVSIAVVFWP SLWRFSLNAL GGAWEWAGRG GRGGLPLYWR LFWLGMFSVL CTGVLGLTLK 

       130        140        150        160        170        180 
ATFEHVFASP LMIAGTLTLT GILLWWTDRL APRRRGLKGI NLKVAGVIGL AQGFALMPGL 

       190        200        210        220        230        240 
SRSAMTIVFA LFTGLKRRWA AEYSFFLAIP TICAATLLQA IEVYRLGLPN TVGFSALAVG 

       250        260        270        280        290 
FVVAAIVGII SLKLVIYFLY RARLKVFSFY VWALALGIAT GLIDLAPALG 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000453 Genomic DNA. Translation: ABI56175.1.
RefSeqYP_741665.1. NC_008340.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING187272.Mlg_0821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI56175; ABI56175; Mlg_0821.
GeneID4268246.
KEGGaeh:Mlg_0821.
PATRIC20860869. VBIAlkEhr114327_0820.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMALVPAWIG.
OrthoDBEOG6QP13M.
ProtClustDBCLSK727247.

Enzyme and pathway databases

BioCycAEHR187272:GHAX-849-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_ALKEH
AccessionPrimary (citable) accession number: Q0AAG2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families