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Q0AAG2

- UPPP_ALKEH

UniProt

Q0AAG2 - UPPP_ALKEH

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciAEHR187272:GHAX-849-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Mlg_0821
    OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
    Taxonomic identifieri187272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
    ProteomesiUP000001962: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Undecaprenyl-diphosphatasePRO_0000290680Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187272.Mlg_0821.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei49 – 6921HelicalUniRule annotationAdd
    BLAST
    Transmembranei101 – 12121HelicalUniRule annotationAdd
    BLAST
    Transmembranei126 – 14621HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei203 – 22321HelicalUniRule annotationAdd
    BLAST
    Transmembranei232 – 25221HelicalUniRule annotationAdd
    BLAST
    Transmembranei266 – 28621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0AAG2-1 [UniParc]FASTAAdd to Basket

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    MALWIAALLG VIQGIFMFLP VSSTAHMVLT EHWLIARGET LPPPESAEMI    50
    LFALVVHVGT LVSIAVVFWP SLWRFSLNAL GGAWEWAGRG GRGGLPLYWR 100
    LFWLGMFSVL CTGVLGLTLK ATFEHVFASP LMIAGTLTLT GILLWWTDRL 150
    APRRRGLKGI NLKVAGVIGL AQGFALMPGL SRSAMTIVFA LFTGLKRRWA 200
    AEYSFFLAIP TICAATLLQA IEVYRLGLPN TVGFSALAVG FVVAAIVGII 250
    SLKLVIYFLY RARLKVFSFY VWALALGIAT GLIDLAPALG 290
    Length:290
    Mass (Da):31,495
    Last modified:October 17, 2006 - v1
    Checksum:i9A92515DF581D1ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI56175.1.
    RefSeqiYP_741665.1. NC_008340.1.

    Genome annotation databases

    EnsemblBacteriaiABI56175; ABI56175; Mlg_0821.
    GeneIDi4268246.
    KEGGiaeh:Mlg_0821.
    PATRICi20860869. VBIAlkEhr114327_0820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI56175.1 .
    RefSeqi YP_741665.1. NC_008340.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187272.Mlg_0821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI56175 ; ABI56175 ; Mlg_0821 .
    GeneIDi 4268246.
    KEGGi aeh:Mlg_0821.
    PATRICi 20860869. VBIAlkEhr114327_0820.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci AEHR187272:GHAX-849-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

    Entry informationi

    Entry nameiUPPP_ALKEH
    AccessioniPrimary (citable) accession number: Q0AAG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3