Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q0AAG2

- UPPP_ALKEH

UniProt

Q0AAG2 - UPPP_ALKEH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-849-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Mlg_0821
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Undecaprenyl-diphosphatasePRO_0000290680Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187272.Mlg_0821.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei49 – 6921HelicalUniRule annotationAdd
BLAST
Transmembranei101 – 12121HelicalUniRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Transmembranei203 – 22321HelicalUniRule annotationAdd
BLAST
Transmembranei232 – 25221HelicalUniRule annotationAdd
BLAST
Transmembranei266 – 28621HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0AAG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALWIAALLG VIQGIFMFLP VSSTAHMVLT EHWLIARGET LPPPESAEMI
60 70 80 90 100
LFALVVHVGT LVSIAVVFWP SLWRFSLNAL GGAWEWAGRG GRGGLPLYWR
110 120 130 140 150
LFWLGMFSVL CTGVLGLTLK ATFEHVFASP LMIAGTLTLT GILLWWTDRL
160 170 180 190 200
APRRRGLKGI NLKVAGVIGL AQGFALMPGL SRSAMTIVFA LFTGLKRRWA
210 220 230 240 250
AEYSFFLAIP TICAATLLQA IEVYRLGLPN TVGFSALAVG FVVAAIVGII
260 270 280 290
SLKLVIYFLY RARLKVFSFY VWALALGIAT GLIDLAPALG
Length:290
Mass (Da):31,495
Last modified:October 17, 2006 - v1
Checksum:i9A92515DF581D1ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI56175.1.
RefSeqiYP_741665.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI56175; ABI56175; Mlg_0821.
GeneIDi4268246.
KEGGiaeh:Mlg_0821.
PATRICi20860869. VBIAlkEhr114327_0820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI56175.1 .
RefSeqi YP_741665.1. NC_008340.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_0821.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI56175 ; ABI56175 ; Mlg_0821 .
GeneIDi 4268246.
KEGGi aeh:Mlg_0821.
PATRICi 20860869. VBIAlkEhr114327_0820.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci AEHR187272:GHAX-849-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiUPPP_ALKEH
AccessioniPrimary (citable) accession number: Q0AAG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3