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Q0AA60 (Q0AA60_ALHEH) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A HAMAP-Rule MF_01897
EC=5.99.1.3 HAMAP-Rule MF_01897
Gene names
Name:gyrA HAMAP-Rule MF_01897
Ordered Locus Names:Mlg_0923
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP] EMBL ABI56277.1
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola ›

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q0AA60 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 62F937355A1FA1A1

FASTA86295,111
        10         20         30         40         50         60 
MASVAREILP VNLEDEMRQS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMRELGNDWN 

        70         80         90        100        110        120 
KSYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFAMRY MLVDGQGNFG SIDGDAAAAM 

       130        140        150        160        170        180 
RYTEVRMSRL AHELLADIEK ETVDYLDNYD GSESEPTVLP TRVPNLLVNG GSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNIREV IDACVALIDD DSLDVDALMQ YLPGPDLPTA GIINGTAGIH EAYRTGRGRM 

       250        260        270        280        290        300 
VMRARARIEE DDKSGKARII VSELPYQVNK ARLLEKIAEL VKEKRVEGIT ELRDESDKDG 

       310        320        330        340        350        360 
IRVVIELRRG EVGEVVLNNL YQHTQLQTVF GINMVALVDG QPKLLNLRQI LDAFVRHRRE 

       370        380        390        400        410        420 
VVTRRTIFEL RKARNRAHVL EGLAVALANI DPVIALIKAS PGPAEAKTAL MSRVWAPGMV 

       430        440        450        460        470        480 
TDMLERADAT TPDDLSPDVG LGEDGYRLSA AQAQAILELR LHRLTGLEQE KILEEYRGLL 

       490        500        510        520        530        540 
EQIGELIHIL ESGERLMEVI REELVAIREQ YGDERRSEII PQALDLTLED LITPQDVVVT 

       550        560        570        580        590        600 
LSHSGYAKSQ PLDSYRAQRR GGRGKSATAM KDADFVDKLF VANTHDTLLC FSSHGKCYWL 

       610        620        630        640        650        660 
KVYELPQGSR QSRGKPIVNL LPLEPDERIN AVLPVQEFDD AHFVFMATHN GTVKKTPLSH 

       670        680        690        700        710        720 
FSRPRSNGII ALDLRADDWL VDVAITDGSR DVMLVSDAGK AIRFEESQVR AMGRTAAGVR 

       730        740        750        760        770        780 
GIRLEPGQRV IALLILDDGD ILSATANGYG KRTPVEEYPR RGRGGMGVIC IQTSDRNGEV 

       790        800        810        820        830        840 
VGAVQVADED EIMLITRHGT LVRTPVADIS RLSRNTQGVK LISLDEDETL VGLERIEALG 

       850        860 
DDDDDDEAGA AADDGSGPPD PA

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References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI56277.1.
RefSeqYP_741767.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0AA60.
SMRQ0AA60. Positions 30-519, 533-837.
ModBaseSearch...

Protein-protein interaction databases

STRING187272.Mlg_0923.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI56277; ABI56277; Mlg_0923.
GeneID4269308.
KEGGaeh:Mlg_0923.
PATRIC20861079. VBIAlkEhr114327_0924.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycAEHR187272:GHAX-979-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0AA60_ALHEH
AccessionPrimary (citable) accession number: Q0AA60
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info