Q0AA54 (AROA_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Mlg_0929

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000071735

Sequences

	Sequence		Length	Mass (Da)
	Q0AA54 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 90345B9320E42B1D	FASTA	446	46,758
	10 20 30 40 50 60 MEFHVRPGGA LRGRLRVPGD KSISHRAIML GALAEGETRI SGFLEGADAL ATLRTFRAMG 70 80 90 100 110 120 VDIDGPHQGR VTVQGVGLHG LRAPDGPLDL GNSGTSMRLL CGLLAGQSFD TTLTGDASLS 130 140 150 160 170 180 RRPMRRVIDP LTAMGAVIES GQGGTAPLTV RGGQPLHGID YELPVASAQV KSALLLAGLY 190 200 210 220 230 240 ARGRTCVTEP APTRDHTERM LAGFGYPVRQ EGRRVCIEGG GRLRGGEIDV PADISSAAFF 250 260 270 280 290 300 LVGASIAEGS DITLEHVGMN PTRTGVVDIL RLMGADIQVQ NEREVGGEPV ADLRVRSAPL 310 320 330 340 350 360 KGVAIPEALV PLAIDEFPVL FVAAACAEGE TLLTGAEELR VKESDRIAVM AEGLTTLGVT 370 380 390 400 410 420 AEPQPDGMRI VGQPDWGGGR VHSHGDHRIA MAFTMAATRA REPIEIEDCA NVNTSFPGFV 430 440 ELAGDAGVAL TRGDAEGRAQ QRSDSP

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MLHE-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000453 Genomic DNA. Translation: ABI56283.1.
RefSeq	YP_741773.1. NC_008340.1.
3D structure databases
ProteinModelPortal	Q0AA54.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0AA54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4268216.
GenomeReviews	Gene locus Mlg_0929 in contig CP000453_GR.
KEGG	aeh:Mlg_0929.
NMPDR	fig|187272.6.peg.897.
PATRIC	20861091. VBIAlkEhr114327_0930.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	LECANIS.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	AEHR187272:MLG_0929-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_ALHEH

Accession

Primary (citable) accession number: Q0AA54

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program