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Q0AA39

- GCH4_ALKEH

UniProt

Q0AA39 - GCH4_ALKEH

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei156 – 1561May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciAEHR187272:GHAX-973-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Mlg_0944
    OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
    Taxonomic identifieri187272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
    ProteomesiUP000001962: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273GTP cyclohydrolase FolE2PRO_0000289472Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi187272.Mlg_0944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0AA39.
    SMRiQ0AA39. Positions 24-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0AA39-1 [UniParc]FASTAAdd to Basket

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    MPEAEKLATV SIEDVQARQD SRRIPINKVG IKDIRHPVRV GGRDGQEQHT    50
    VANFSMYVNL PQHFKGTHMS RFVQILEGHD TEITVQSFRE MLHEVAERLE 100
    AESGHIEMAF PLFVRKTAPV TGVQSLMDYQ VAFIGEIHEG EPELAIRVVV 150
    PVTSLCPCSK EISRYGAHNQ RSHVTVTAKT RDLLWVEDLI DLVEEEASCE 200
    LYGLLKRPDE KYVTERAYEN PKFVEDLVRD VAIRLNDEDR VLAYNVTAEN 250
    FESIHNHSAF AEIEHDKTGE PRR 273
    Length:273
    Mass (Da):31,182
    Last modified:October 17, 2006 - v1
    Checksum:i911EE77EA8228014
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI56298.1.
    RefSeqiYP_741788.1. NC_008340.1.

    Genome annotation databases

    EnsemblBacteriaiABI56298; ABI56298; Mlg_0944.
    GeneIDi4269678.
    KEGGiaeh:Mlg_0944.
    PATRICi20861121. VBIAlkEhr114327_0945.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI56298.1 .
    RefSeqi YP_741788.1. NC_008340.1.

    3D structure databases

    ProteinModelPortali Q0AA39.
    SMRi Q0AA39. Positions 24-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187272.Mlg_0944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI56298 ; ABI56298 ; Mlg_0944 .
    GeneIDi 4269678.
    KEGGi aeh:Mlg_0944.
    PATRICi 20861121. VBIAlkEhr114327_0945.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci AEHR187272:GHAX-973-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

    Entry informationi

    Entry nameiGCH4_ALKEH
    AccessioniPrimary (citable) accession number: Q0AA39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3