Reviewed, UniProtKB/Swiss-Prot Q0A9D7 (HIS3_ALHEH)

Names and origin

Protein names

Recommended name:
    Phosphoribosyl-AMP cyclohydrolase
      Short name=PRA-CH
    EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	Mlg_1201

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000319681

Sequences

	Sequence		Length	Mass (Da)
	Q0A9D7-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 2C58B9AB653E5F12	FASTA	142	16,126
	10 20 30 40 50 60 MFKDLEKARP GTRRDLPAVL AALPWNAQGL LPAIAQQHDS GEVLMMAWMN REALEETLRT 70 80 90 100 110 120 GRVCYYSRSR RSLWRKGESS GQVQRLVELR LDCDGDTLLL RVDQTGPACH TGRRSCFYNR 130 140 LDGDGLEVIA APEIDPETLY HR

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000453 Genomic DNA. Translation: ABI56550.1.
RefSeq	YP_742040.1.
3D structure databases
SMR	Q0A9D7. Positions 22-133.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0A9D7.
Genome annotation databases
GeneID	4270689.
GenomeReviews	Gene locus Mlg_1201 in contig CP000453_GR.
KEGG	aeh:Mlg_1201.
NMPDR	fig|187272.6.peg.1149.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0139.
HOGENOM	HBG294308.
OMA	GRRTCFH.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRA_CycHdrlase. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_ALHEH

Accession

Primary (citable) accession number: Q0A9D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 17, 2006
Last modified:	January 19, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)