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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAEHR187272:G1G7A-1248-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:Mlg_1214
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
Proteomesi
  • UP000001962 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000151741 – 345S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST345

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi187272.Mlg_1214.

Structurei

3D structure databases

ProteinModelPortaliQ0A9C4.
SMRiQ0A9C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N. Bacteria.
COG0809. LUCA.
HOGENOMiHOG000004403.
KOiK07568.
OMAiYSYGDGM.
OrthoDBiPOG091H00ZG.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiView protein in InterPro
IPR003699. QueA.
IPR036100. QueA_sf.
PANTHERiPTHR30307. PTHR30307. 1 hit.
PfamiView protein in Pfam
PF02547. Queuosine_synth. 1 hit.
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0A9C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVDDFSFDL PEALIAHHPP EQRRDSRLLC LDRDTGAVAD RRFPDLVDLL
60 70 80 90 100
RPEDLLVLND TRVIPARLFG HKPTGGRVEV LVERPLDRHR VLARLRASKV
110 120 130 140 150
PAPGTVLTLE GGVAAEVTGR EGEFFTLRFT AEQTVLELLE HHGHMPLPPY
160 170 180 190 200
IRRADVAADR ERYQTVFARR PGAVAAPTAG LHFDNELLAR IGARGVDTAW
210 220 230 240 250
VTLHVGSGTF APLRVSDPRE HRMHSEWLDV PPATCAAIER ARGRGGRVVA
260 270 280 290 300
VGTTVVRALE TAAQDGAVQP YQGETDIFIY PGHRFHAVDA LVTNFHLPGS
310 320 330 340
TLLMLVSAFA GRERVLAAYR HAVAQRYRFF SYGDAMFIAA GAADE
Length:345
Mass (Da):38,069
Last modified:October 17, 2006 - v1
Checksum:i70962D1D3577670D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA. Translation: ABI56563.1.
RefSeqiWP_011628958.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI56563; ABI56563; Mlg_1214.
KEGGiaeh:Mlg_1214.

Similar proteinsi

Entry informationi

Entry nameiQUEA_ALKEH
AccessioniPrimary (citable) accession number: Q0A9C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome