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Q0A9B2 (AROC_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Mlg_1226
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Chorismate synthase HAMAP MF_00300
PRO_0000322383

Sequences

Sequence LengthMass (Da)Tools
Q0A9B2 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 74E77B07CC9DE868

FASTA36639,215
        10         20         30         40         50         60 
MSGNTIGKLF TVTTFGESHG PALGAIVDGC PPGLALSEAD LQRDLDRRRP GTSKFTTQRK 

        70         80         90        100        110        120 
EPDQVRILSG VFEGRTTGTP IGLLIENTDQ RSKDYAEIAR RFRPGHADYT YLQKYGIRDY 

       130        140        150        160        170        180 
RGGGRSSARE TAMRVAAGGI ARKYLRERLG VTVQGCLTQL GPIELGIKDW MAVDDNPFFC 

       190        200        210        220        230        240 
ADPERVPDLE SFMQDLRKAG NSIGAAVTVV ARGCPPGLGE PVFDRLDADL AHALMSINAV 

       250        260        270        280        290        300 
KGVELGAGFA SVMQHGSEHR DELTPEGFAS NNAGGVLGGL STGQDVVTRI ALKPTSSIVV 

       310        320        330        340        350        360 
PGRTIDTEGE PVPVVTKGRH DPCVGIRAVP IAEAMVALTL MDHWLRHRAQ CADVQPETPP 


IPAANR

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI56575.1.
RefSeqYP_742065.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0A9B2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0A9B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4269757.
GenomeReviewsGene locus Mlg_1226 in contig CP000453_GR.
KEGGaeh:Mlg_1226.
NMPDRfig|187272.6.peg.1174.
PATRIC20861683. VBIAlkEhr114327_1223.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
OMASRFTTQR.
PhylomeDBQ0A9B2.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycAEHR187272:MLG_1226-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. False negative.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_ALHEH
AccessionPrimary (citable) accession number: Q0A9B2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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