ID   SYH_ALHEH               Reviewed;         429 AA.
AC   Q0A986;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Histidyl-tRNA synthetase;
DE            EC=6.1.1.21;
DE   AltName: Full=Histidine--tRNA ligase;
DE            Short=HisRS;
GN   Name=hisS; OrderedLocusNames=Mlg_1252;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP +
CC       diphosphate + L-histidyl-tRNA(His).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family.
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DR   EMBL; CP000453; ABI56601.1; -; Genomic_DNA.
DR   RefSeq; YP_742091.1; -.
DR   GeneID; 4269174; -.
DR   GenomeReviews; CP000453_GR; Mlg_1252.
DR   KEGG; aeh:Mlg_1252; -.
DR   NMPDR; fig|187272.6.peg.1200; -.
DR   HOGENOM; Q0A986; -.
DR   OMA; Q0A986; VFEWVTT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:HAMAP.
DR   GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:HAMAP.
DR   HAMAP; MF_00127; -; 1.
DR   InterPro; IPR002314; aa-tRNA-synt_IIb_cons-reg.
DR   InterPro; IPR006195; aa-tRNA-synth_II_cons-reg.
DR   InterPro; IPR004154; Anticodon_bd.
DR   InterPro; IPR015807; His-tRNA-synth_IIa_sub.
DR   InterPro; IPR004516; His-tRNA_synth_IIA.
DR   Gene3D; G3DSA:3.40.50.800; Anticodon_bd; 1.
DR   PANTHER; PTHR11476; His-tRNA_synth; 1.
DR   Pfam; PF03129; HGTP_anticodon; 1.
DR   Pfam; PF00587; tRNA-synt_2b; 1.
DR   PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR   TIGRFAMs; TIGR00442; hisS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Protein biosynthesis.
FT   CHAIN         1    429       Histidyl-tRNA synthetase.
FT                                /FTId=PRO_1000016308.
SQ   SEQUENCE   429 AA;  47922 MW;  DDE09E5CBB8133B9 CRC64;
     MAKGIRSIRG FSDILPEQTP LWQFVESNIQ ATLEAYGYRE IRLPIVEKTE LFSRSIGEVT
     DIVEKEMYTF EDRNGDSLTL RPEGTAGCVR CGIQNGLFHG GQPRVWYAGP MFRHERPQKG
     RYRQFHQIGA EVYGESGPGV DAEMILMTAR LLRCLGLEDV RLELNTLGTG EARAAHRAAL
     VEYLQAHEDR LDDDARRRLH SNPLRILDTK NPDMQALVEQ APRLMDYLDE DSRSHFQAVC
     RVLDQAGVAY RVNPRLVRGL DYYSRTVFEW ITDRLGAQGT VLAGGRYDTL VEQIGGKPTP
     AIGFALGLER LVSLLEESGI SGPQSGPHAF VVSADSLRAL PLVEGLRDRL PGLRLQMQTE
     GGSFRSQFKR ADRSGAALAL VLGEEELAEG RFGVKDLRGD AEQQRLDPEA LSDYLARRWP
     ELAATEVTD
//