Reviewed, UniProtKB/Swiss-Prot Q0A986 (SYH_ALHEH)

Names and origin

Protein names

Recommended name:
    Histidyl-tRNA synthetase
    EC=6.1.1.21
Alternative name(s):
    Histidine--tRNA ligase
      Short name=HisRS

Gene names

Name:	hisS
Ordered Locus Names:	Mlg_1252

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP MF_00127
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP histidine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Histidyl-tRNA synthetase HAMAP MF_00127		PRO_1000016308

Sequences

	Sequence		Length	Mass (Da)
	Q0A986-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: DDE09E5CBB8133B9	FASTA	429	47,922
	10 20 30 40 50 60 MAKGIRSIRG FSDILPEQTP LWQFVESNIQ ATLEAYGYRE IRLPIVEKTE LFSRSIGEVT 70 80 90 100 110 120 DIVEKEMYTF EDRNGDSLTL RPEGTAGCVR CGIQNGLFHG GQPRVWYAGP MFRHERPQKG 130 140 150 160 170 180 RYRQFHQIGA EVYGESGPGV DAEMILMTAR LLRCLGLEDV RLELNTLGTG EARAAHRAAL 190 200 210 220 230 240 VEYLQAHEDR LDDDARRRLH SNPLRILDTK NPDMQALVEQ APRLMDYLDE DSRSHFQAVC 250 260 270 280 290 300 RVLDQAGVAY RVNPRLVRGL DYYSRTVFEW ITDRLGAQGT VLAGGRYDTL VEQIGGKPTP 310 320 330 340 350 360 AIGFALGLER LVSLLEESGI SGPQSGPHAF VVSADSLRAL PLVEGLRDRL PGLRLQMQTE 370 380 390 400 410 420 GGSFRSQFKR ADRSGAALAL VLGEEELAEG RFGVKDLRGD AEQQRLDPEA LSDYLARRWP ELAATEVTD

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI56601.1.
RefSeq	YP_742091.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4269174.
GenomeReviews	Gene locus Mlg_1252 in contig CP000453_GR.
KEGG	aeh:Mlg_1252.
NMPDR	fig|187272.6.peg.1200.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0A986.
OMA	Q0A986. VFEWVTT.
Family and domain databases
HAMAP	MF_00127. [Tree]
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-reg. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004154. Anticodon_bd. IPR015807. His-tRNA-synth_IIa_sub. IPR004516. His-tRNA_synth_IIA. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PANTHER	PTHR11476. His-tRNA_synth. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. [Graphical view]
PIRSF	PIRSF001549. His-tRNA_synth. 1 hit.
TIGRFAMs	TIGR00442. hisS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYH_ALHEH

Accession

Primary (citable) accession number: Q0A986

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)