Reviewed,
UniProtKB/Swiss-Prot Q0A939 (GCH1_ALHEH)
Last modified
February 9, 2010.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: GTP cyclohydrolase 1 EC=3.5.4.16 Alternative name(s): GTP cyclohydrolase I Short name=GTP-CH-I | ||||
| Gene names |
| ||||
| Organism | Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 187272 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola |
Protein attributes
| Sequence length | 185 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 |
| Pathway | Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 |
| Subunit structure | Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity. HAMAP MF_00223 |
| Sequence similarities | Belongs to the GTP cyclohydrolase I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Ligand | GTP-binding Metal-binding Nucleotide-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activityInferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 185 | 185 | GTP cyclohydrolase 1 HAMAP MF_00223 | PRO_1000043656 | |||||
Sites | |||||||||
| Metal binding | 75 | 1 | Zinc By similarity | ||||||
| Metal binding | 78 | 1 | Zinc By similarity | ||||||
| Metal binding | 146 | 1 | Zinc By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. Richardson P.Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000453 Genomic DNA. Translation: ABI56648.1. |
| RefSeq | YP_742138.1. |
3D structure databases | |
| SMR | Q0A939. Positions 5-184. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q0A939. |
Genome annotation databases | |
| GeneID | 4269066. |
| GenomeReviews | Gene locus Mlg_1299 in contig CP000453_GR. |
| KEGG | aeh:Mlg_1299. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0302. |
| HOGENOM | HBG370191. |
| OMA | MAPIIGR. |
| PhylomeDB | Q0A939. |
Family and domain databases | |
| HAMAP | MF_00223. FolE. [Tree] |
| InterPro | IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view] |
| Pfam | PF01227. GTP_cyclohydroI. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00063. folE. 1 hit. |
| PROSITE | PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GCH1_ALHEH | ||||||||
| Accession | Primary (citable) accession number: Q0A939 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


