Reviewed, UniProtKB/Swiss-Prot Q0A911 (NAGZ_ALHEH)

Names and origin

Protein names

Recommended name:
    Beta-hexosaminidase
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	Mlg_1327

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Beta-hexosaminidase HAMAP MF_00364		PRO_1000005650
Sites
	Active site	252	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0A911-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 394B20284FA162DC	FASTA	348	38,045
	10 20 30 40 50 60 MLLGPLMMGL EGTRLSSEER TLLCHPRVGG VILFSRNFQS PEQLRALTDA IHALRRPPLL 70 80 90 100 110 120 IAVDQEGGRV QRFREGFTRL PAPGVLAAVY DRDPAQARAL SHDMGWLMAS ELLACGVDFS 130 140 150 160 170 180 FAPVLDLGRG VSRVIGDRAF HSRPEAVVHL ARGWVAGMRD AGMAAVGKHF PGHGSVAPDS 190 200 210 220 230 240 HLELPRDPRA RSALEGADLV PFRRLAGDRL PGMMTAHVIY QAIDPLPATF SGYWIGEVLR 250 260 270 280 290 300 GELGYEGAVF SDDLGMAAAA EAGPLPRRAR AAMEAGCDMV LLCNHPEAVP AVLRHLPDPD 310 320 330 340 PVSDMRLVRL HGRPVVDNWR KLHRLTRWQE AVRRVRGQDP SPEGELEV

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI56676.1.
RefSeq	YP_742166.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0A911.
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Genome annotation databases
GeneID	4268666.
GenomeReviews	Gene locus Mlg_1327 in contig CP000453_GR.
KEGG	aeh:Mlg_1327.
NMPDR	fig|187272.6.peg.1273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0A911.
OMA	ADSHIAQ.
Family and domain databases
HAMAP	MF_00364. [Tree]
InterPro	IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_ALHEH

Accession

Primary (citable) accession number: Q0A911

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)