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Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192S-adenosyl-L-methionineUniRule annotation1
Binding sitei244S-adenosyl-L-methionineUniRule annotation1
Binding sitei264S-adenosyl-L-methionineUniRule annotation1
Binding sitei280S-adenosyl-L-methionineUniRule annotation1
Active sitei309Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAEHR187272:G1G7A-1531-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:Mlg_1490
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
Proteomesi
  • UP000001962 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145081 – 360Ribosomal RNA large subunit methyltransferase MAdd BLAST360

Proteomic databases

PRIDEiQ0A8J8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi187272.Mlg_1490

Structurei

3D structure databases

ProteinModelPortaliQ0A8J8
SMRiQ0A8J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni225 – 228S-adenosyl-L-methionine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6 Bacteria
COG2933 LUCA
HOGENOMiHOG000247137
KOiK06968
OMAiPVDWMVC
OrthoDBiPOG091H04R8

Family and domain databases

HAMAPiMF_01551 23SrRNA_methyltr_M, 1 hit
InterProiView protein in InterPro
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR011224 rRNA_MeTrfase_M
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF01728 FtsJ, 1 hit
PIRSFiPIRSF028774 UCP028774, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q0A8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERDPIPTR HATRWLLQCR PGFGADLAAE LAAWSSDAGV AGWPRVENDQ
60 70 80 90 100
GRVDFHSADG RPLPTPPALT FARQAWPVVA DCPQLPERDR VGALLEALAP
110 120 130 140 150
HLPEALAGVW LEHPDTNDGK ALGRFCRKFR PHLERALRER GVALERAGAP
160 170 180 190 200
RLHLWFADSR QVVAGLAPAG SGRPWPMGIP RLRLPRAAPS RSALKLEEAV
210 220 230 240 250
GWLLTPVERE AALRPGMSAV DLGAAPGGWT WVLRQAGLHV TAVDNGPLAE
260 270 280 290 300
SLRADRAVRH LREDGFRYRP PHRVDWLVCD MVEQPHRVAR LVRHWLVSGW
310 320 330 340 350
CGRALFNLKL PMRRRWQCVA ECRALVTGGS GELGWRSAQL YHDREEITVL
360
AWRPAAGSRG
Length:360
Mass (Da):39,961
Last modified:October 17, 2006 - v1
Checksum:i81F9D6BEB04D0B30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA Translation: ABI56839.1
RefSeqiWP_011629234.1, NC_008340.1

Genome annotation databases

EnsemblBacteriaiABI56839; ABI56839; Mlg_1490
KEGGiaeh:Mlg_1490

Entry informationi

Entry nameiRLMM_ALKEH
AccessioniPrimary (citable) accession number: Q0A8J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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