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Q0A845

- MASZ_ALKEH

UniProt

Q0A845 - MASZ_ALKEH

Protein

Malate synthase G

Gene

glcB

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Binding sitei280 – 2801Acetyl-CoAUniRule annotation
    Binding sitei317 – 3171Acetyl-CoAUniRule annotation
    Active sitei344 – 3441Proton acceptorUniRule annotation
    Binding sitei344 – 3441GlyoxylateUniRule annotation
    Metal bindingi436 – 4361MagnesiumUniRule annotation
    Binding sitei436 – 4361GlyoxylateUniRule annotation
    Metal bindingi464 – 4641MagnesiumUniRule annotation
    Binding sitei545 – 5451Acetyl-CoA; via carbonyl oxygenUniRule annotation
    Active sitei635 – 6351Proton donorUniRule annotation

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-HAMAP
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciAEHR187272:GHAX-1690-MONOMER.
    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
    Gene namesi
    Name:glcBUniRule annotation
    Ordered Locus Names:Mlg_1646
    OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
    Taxonomic identifieri187272 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
    ProteomesiUP000001962: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Malate synthase GPRO_1000130886Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei621 – 6211Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi187272.Mlg_1646.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0A845.
    SMRiQ0A845. Positions 2-726.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
    Regioni461 – 4644Glyoxylate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2225.
    HOGENOMiHOG000220740.
    KOiK01638.
    OrthoDBiEOG6HJ286.

    Family and domain databases

    Gene3Di2.170.170.11. 2 hits.
    HAMAPiMF_00641. Malate_synth_G.
    InterProiIPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q0A845-1 [UniParc]FASTAAdd to Basket

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    MTQRIEVGGL QVAQELYDLV AKEIAPATGV DADGFWTHLG AIVRDLGARN    50
    RELLQKRDEI QQAIDKWHLE RKGQPHDAAA YKTFLEELGY LQPEGEDFEA 100
    TTENVDPEIA EVAGPQLVVP INNARFALNA ANARWGSLYD ALYGSDVLPE 150
    DDGAEKGTRY NPVRGKKVME YAGRVLDEVA PLAQGRHGDV VAYNLVDDNG 200
    RKRLQARLSD GSETGLADPE GLAGYNGAED DPTVLLLRHN GLHVEIQIDR 250
    EHLIGKDHPA GVKDVVMEAA VTAIMDCEDS VAAVDAEDKT AVYRNWLGLM 300
    NGDLETSLEK GGKTIQRRLN ADRDYIGADG RALTLPGRSL MLIRNVGHLM 350
    TTPAVLDADG NEIPEGILDG MVTSLIALYD LKGLGRYRNS RSGSMYIVKP 400
    KMHGPDEVAF AVELFGRIED ALGMERNTLK IGVMDEERRT TVNLKACIRE 450
    AKERIIFINT GFLDRTGDEM HTSMEAGPMI RKAEMKSSRW LNAYEDWNVD 500
    IGLECGLRGR AQIGKGMWTM PDLMKGMMEA KIGHPKAGAN CAWVPSPTAA 550
    TLHAIHYHQV NVAEVQDRLA GQRRATLDDL LTIPLEPSPS WSAEEIQQEL 600
    DNNCQGILGY VVRWVDQGIG CSKVPDINNV GLMEDRATLR IASQLLANWL 650
    HHGICSEEQI METMKRMAKV VDQQNAGDPN YRPMAADYDG SVAFQAACEL 700
    VLKGREQPSG YTEPVLHRRR REAKAKFGA 729
    Length:729
    Mass (Da):80,444
    Last modified:October 17, 2006 - v1
    Checksum:i05A52DB21B7F6187
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI56992.1.
    RefSeqiYP_742482.1. NC_008340.1.

    Genome annotation databases

    EnsemblBacteriaiABI56992; ABI56992; Mlg_1646.
    GeneIDi4270247.
    KEGGiaeh:Mlg_1646.
    PATRICi20862557. VBIAlkEhr114327_1649.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000453 Genomic DNA. Translation: ABI56992.1 .
    RefSeqi YP_742482.1. NC_008340.1.

    3D structure databases

    ProteinModelPortali Q0A845.
    SMRi Q0A845. Positions 2-726.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 187272.Mlg_1646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI56992 ; ABI56992 ; Mlg_1646 .
    GeneIDi 4270247.
    KEGGi aeh:Mlg_1646.
    PATRICi 20862557. VBIAlkEhr114327_1649.

    Phylogenomic databases

    eggNOGi COG2225.
    HOGENOMi HOG000220740.
    KOi K01638.
    OrthoDBi EOG6HJ286.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .
    BioCyci AEHR187272:GHAX-1690-MONOMER.

    Family and domain databases

    Gene3Di 2.170.170.11. 2 hits.
    HAMAPi MF_00641. Malate_synth_G.
    InterProi IPR011076. Malate_synth-like.
    IPR023310. Malate_synth_G_beta_sub_dom.
    IPR001465. Malate_synthase.
    IPR006253. Malate_synthG.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

    Entry informationi

    Entry nameiMASZ_ALKEH
    AccessioniPrimary (citable) accession number: Q0A845
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3