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Q0A845

- MASZ_ALKEH

UniProt

Q0A845 - MASZ_ALKEH

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Protein
Malate synthase G
Gene
glcB, Mlg_1646
Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei280 – 2801Acetyl-CoA By similarity
Binding sitei317 – 3171Acetyl-CoA By similarity
Active sitei344 – 3441Proton acceptor By similarity
Binding sitei344 – 3441Glyoxylate By similarity
Metal bindingi436 – 4361Magnesium By similarity
Binding sitei436 – 4361Glyoxylate By similarity
Metal bindingi464 – 4641Magnesium By similarity
Binding sitei545 – 5451Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei635 – 6351Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-1690-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Mlg_1646
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Malate synthase GUniRule annotation
PRO_1000130886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei621 – 6211Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi187272.Mlg_1646.

Structurei

3D structure databases

ProteinModelPortaliQ0A845.
SMRiQ0A845. Positions 2-726.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni461 – 4644Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0A845-1 [UniParc]FASTAAdd to Basket

« Hide

MTQRIEVGGL QVAQELYDLV AKEIAPATGV DADGFWTHLG AIVRDLGARN    50
RELLQKRDEI QQAIDKWHLE RKGQPHDAAA YKTFLEELGY LQPEGEDFEA 100
TTENVDPEIA EVAGPQLVVP INNARFALNA ANARWGSLYD ALYGSDVLPE 150
DDGAEKGTRY NPVRGKKVME YAGRVLDEVA PLAQGRHGDV VAYNLVDDNG 200
RKRLQARLSD GSETGLADPE GLAGYNGAED DPTVLLLRHN GLHVEIQIDR 250
EHLIGKDHPA GVKDVVMEAA VTAIMDCEDS VAAVDAEDKT AVYRNWLGLM 300
NGDLETSLEK GGKTIQRRLN ADRDYIGADG RALTLPGRSL MLIRNVGHLM 350
TTPAVLDADG NEIPEGILDG MVTSLIALYD LKGLGRYRNS RSGSMYIVKP 400
KMHGPDEVAF AVELFGRIED ALGMERNTLK IGVMDEERRT TVNLKACIRE 450
AKERIIFINT GFLDRTGDEM HTSMEAGPMI RKAEMKSSRW LNAYEDWNVD 500
IGLECGLRGR AQIGKGMWTM PDLMKGMMEA KIGHPKAGAN CAWVPSPTAA 550
TLHAIHYHQV NVAEVQDRLA GQRRATLDDL LTIPLEPSPS WSAEEIQQEL 600
DNNCQGILGY VVRWVDQGIG CSKVPDINNV GLMEDRATLR IASQLLANWL 650
HHGICSEEQI METMKRMAKV VDQQNAGDPN YRPMAADYDG SVAFQAACEL 700
VLKGREQPSG YTEPVLHRRR REAKAKFGA 729
Length:729
Mass (Da):80,444
Last modified:October 17, 2006 - v1
Checksum:i05A52DB21B7F6187
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI56992.1.
RefSeqiYP_742482.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI56992; ABI56992; Mlg_1646.
GeneIDi4270247.
KEGGiaeh:Mlg_1646.
PATRICi20862557. VBIAlkEhr114327_1649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI56992.1 .
RefSeqi YP_742482.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0A845.
SMRi Q0A845. Positions 2-726.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_1646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI56992 ; ABI56992 ; Mlg_1646 .
GeneIDi 4270247.
KEGGi aeh:Mlg_1646.
PATRICi 20862557. VBIAlkEhr114327_1649.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci AEHR187272:GHAX-1690-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiMASZ_ALKEH
AccessioniPrimary (citable) accession number: Q0A845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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