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Q0A845

- MASZ_ALKEH

UniProt

Q0A845 - MASZ_ALKEH

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Protein

Malate synthase G

Gene

glcB

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei280 – 2801Acetyl-CoAUniRule annotation
Binding sitei317 – 3171Acetyl-CoAUniRule annotation
Active sitei344 – 3441Proton acceptorUniRule annotation
Binding sitei344 – 3441GlyoxylateUniRule annotation
Metal bindingi436 – 4361MagnesiumUniRule annotation
Binding sitei436 – 4361GlyoxylateUniRule annotation
Metal bindingi464 – 4641MagnesiumUniRule annotation
Binding sitei545 – 5451Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei635 – 6351Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-1690-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Mlg_1646
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Malate synthase GPRO_1000130886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei621 – 6211Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi187272.Mlg_1646.

Structurei

3D structure databases

ProteinModelPortaliQ0A845.
SMRiQ0A845. Positions 2-726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni461 – 4644Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0A845-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQRIEVGGL QVAQELYDLV AKEIAPATGV DADGFWTHLG AIVRDLGARN
60 70 80 90 100
RELLQKRDEI QQAIDKWHLE RKGQPHDAAA YKTFLEELGY LQPEGEDFEA
110 120 130 140 150
TTENVDPEIA EVAGPQLVVP INNARFALNA ANARWGSLYD ALYGSDVLPE
160 170 180 190 200
DDGAEKGTRY NPVRGKKVME YAGRVLDEVA PLAQGRHGDV VAYNLVDDNG
210 220 230 240 250
RKRLQARLSD GSETGLADPE GLAGYNGAED DPTVLLLRHN GLHVEIQIDR
260 270 280 290 300
EHLIGKDHPA GVKDVVMEAA VTAIMDCEDS VAAVDAEDKT AVYRNWLGLM
310 320 330 340 350
NGDLETSLEK GGKTIQRRLN ADRDYIGADG RALTLPGRSL MLIRNVGHLM
360 370 380 390 400
TTPAVLDADG NEIPEGILDG MVTSLIALYD LKGLGRYRNS RSGSMYIVKP
410 420 430 440 450
KMHGPDEVAF AVELFGRIED ALGMERNTLK IGVMDEERRT TVNLKACIRE
460 470 480 490 500
AKERIIFINT GFLDRTGDEM HTSMEAGPMI RKAEMKSSRW LNAYEDWNVD
510 520 530 540 550
IGLECGLRGR AQIGKGMWTM PDLMKGMMEA KIGHPKAGAN CAWVPSPTAA
560 570 580 590 600
TLHAIHYHQV NVAEVQDRLA GQRRATLDDL LTIPLEPSPS WSAEEIQQEL
610 620 630 640 650
DNNCQGILGY VVRWVDQGIG CSKVPDINNV GLMEDRATLR IASQLLANWL
660 670 680 690 700
HHGICSEEQI METMKRMAKV VDQQNAGDPN YRPMAADYDG SVAFQAACEL
710 720
VLKGREQPSG YTEPVLHRRR REAKAKFGA
Length:729
Mass (Da):80,444
Last modified:October 17, 2006 - v1
Checksum:i05A52DB21B7F6187
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA. Translation: ABI56992.1.
RefSeqiYP_742482.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI56992; ABI56992; Mlg_1646.
GeneIDi4270247.
KEGGiaeh:Mlg_1646.
PATRICi20862557. VBIAlkEhr114327_1649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA. Translation: ABI56992.1 .
RefSeqi YP_742482.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0A845.
SMRi Q0A845. Positions 2-726.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_1646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI56992 ; ABI56992 ; Mlg_1646 .
GeneIDi 4270247.
KEGGi aeh:Mlg_1646.
PATRICi 20862557. VBIAlkEhr114327_1649.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci AEHR187272:GHAX-1690-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiMASZ_ALKEH
AccessioniPrimary (citable) accession number: Q0A845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3