Q0A808 (CCMA_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA
EC=3.6.3.41

Alternative name(s):
Heme exporter protein A

Gene names

Name:	ccmA
Ordered Locus Names:	Mlg_1683

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Cytochrome c biogenesis ATP-binding export protein CcmA HAMAP MF_01707		PRO_0000271918
Regions
	Domain	14 – 235	222	ABC transporter
	Nucleotide binding	46 – 53	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0A808 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: AC4EC7BFD378C89E	FASTA	236	25,418
	10 20 30 40 50 60 MGDTALHLVA APALEATGLQ VARGGRPLFR GLGFRLARGG LLCVRGANGS GKTTLLRTLA 70 80 90 100 110 120 GLSRPHRGRI LRAGRCIRQA ANDHRGTLQY RGHRDGLRGA LTVLENLQWQ AALYHHRPDR 130 140 150 160 170 180 EAVRTALAGM GMARHLDTLA SQLSQGQRRR VVLASLALFP RCRLWLLDEP QAALDVEGAE 190 200 210 220 230 RFHALLARHC QEGGAVVACS HQHLRIGGIP CDELWLSDPA PAGARSAGDR VTGTEA

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MLHE-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000453 Genomic DNA. Translation: ABI57029.1.
RefSeq	YP_742519.1. NC_008340.1.
3D structure databases
ProteinModelPortal	Q0A808.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0A808.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4268778.
GenomeReviews	Gene locus Mlg_1683 in contig CP000453_GR.
KEGG	aeh:Mlg_1683.
NMPDR	fig|187272.6.peg.1616.
PATRIC	20862635. VBIAlkEhr114327_1688.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4133.
HOGENOM	HBG758042.
OMA	NIWIIDE.
PhylomeDB	Q0A808.
Enzyme and pathway databases
BioCyc	AEHR187272:MLG_1683-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K02193.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_ALHEH

Accession

Primary (citable) accession number: Q0A808

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program