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Q0A7J2

- LPXB_ALKEH

UniProt

Q0A7J2 - LPXB_ALKEH

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Mlg_1851
Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-1895-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Mlg_1851
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049383Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187272.Mlg_1851.

Structurei

3D structure databases

ProteinModelPortaliQ0A7J2.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0A7J2-1 [UniParc]FASTAAdd to Basket

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MRVALVAGEH SGDRLGAGLI RAIRARCPEA EFDGVGGPLM QAEGLRSHYP    50
MEALSVMGLV EVLRHLPRLL RIRRDLVARY RTDPPDVFVG IDLPDFNLSI 100
ERRLKAVGVP TVHYVSPQVW AWRQGRVRTI GRSVDRILAL YPFEAEFYRR 150
HGVPVDFVGH PAADRFPLQP DAGAARAALG LVDDGGGPWV ALLPGSRLGE 200
VQRHAELYAR TVARLRERQP DVRFIAPLAW PGLRAVFYEA LVQQGVSDAV 250
QLFEGRADEV MAAADVVLTA SGTATLEAML LKRPMVVAYR LAPLTFWLMK 300
RLVRVSHVSQ PNLLAGEGLV EEYLQDAATP DNLAYALYRL LNDEPRSAYL 350
RARFAELHGT LRRGADGQAA AAVLAAAGGN GS 382
Length:382
Mass (Da):41,866
Last modified:October 17, 2006 - v1
Checksum:i6C6A8414633175F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI57195.1.
RefSeqiYP_742685.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI57195; ABI57195; Mlg_1851.
GeneIDi4269219.
KEGGiaeh:Mlg_1851.
PATRICi20862957. VBIAlkEhr114327_1849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI57195.1 .
RefSeqi YP_742685.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0A7J2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_1851.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI57195 ; ABI57195 ; Mlg_1851 .
GeneIDi 4269219.
KEGGi aeh:Mlg_1851.
PATRICi 20862957. VBIAlkEhr114327_1849.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci AEHR187272:GHAX-1895-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiLPXB_ALKEH
AccessioniPrimary (citable) accession number: Q0A7J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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