ID   TPIS_ALHEH              Reviewed;         250 AA.
AC   Q0A773;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Triosephosphate isomerase;
DE            Short=TIM;
DE            EC=5.3.1.1;
DE   AltName: Full=Triose-phosphate isomerase;
GN   Name=tpiA; OrderedLocusNames=Mlg_1972;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate from glycerone phosphate: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR   EMBL; CP000453; ABI57314.1; -; Genomic_DNA.
DR   RefSeq; YP_742804.1; -.
DR   GeneID; 4268515; -.
DR   GenomeReviews; CP000453_GR; Mlg_1972.
DR   KEGG; aeh:Mlg_1972; -.
DR   NMPDR; fig|187272.6.peg.1879; -.
DR   HOGENOM; Q0A773; -.
DR   OMA; Q0A773; IGAQDCH.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR   HAMAP; MF_00147; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000652; Triosephosphate_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR21139; Triophos_ismrse; 1.
DR   Pfam; PF00121; TIM; 1.
DR   ProDom; PD001005; Triophos_ismrse; 1.
DR   TIGRFAMs; TIGR00419; tim; 1.
DR   PROSITE; PS00171; TIM_1; 1.
DR   PROSITE; PS51440; TIM_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW   Pentose shunt.
FT   CHAIN         1    250       Triosephosphate isomerase.
FT                                /FTId=PRO_0000307422.
FT   ACT_SITE     94     94       Electrophile (By similarity).
FT   ACT_SITE    165    165       Proton acceptor (By similarity).
FT   BINDING       9      9       Substrate (By similarity).
FT   BINDING      11     11       Substrate (By similarity).
SQ   SEQUENCE   250 AA;  26220 MW;  75DFB29834414F59 CRC64;
     MRKPMVAGNW KMNGSLALVN DMGRALADVD CSAVDVLVCP PFPYIGPLRR AVPDESGVAL
     GGQDVSRYDS GAYTGEVAGA MLAEMGCRHV IVGHSERRAM HAETDEVVVD KVQAALRAGL
     TPIVCVGETL EARDAGETEQ VVGRQLDAVL ELGGFVVEKL VLAYEPVWAI GTGRTASPEQ
     AQAVHAFIRQ RAADALGDEL AQRLPILYGG SVKPGNAREL FGCADVDGGL IGGASLDPDG
     FLEIISAARP
//